Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome
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The dynamic cilium in human diseasesBardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypesIntrinsic protein-protein interaction-mediated and chaperonin-assisted sequential assembly of stable bardet-biedl syndrome protein complex, the BBSomeBBS mutations modify phenotypic expression of CEP290-related ciliopathiesRequirement of Bardet-Biedl syndrome proteins for leptin receptor signalingThe blind leading the obese: the molecular pathophysiology of a human obesity syndromeRecent advances in understanding leptin signaling and leptin resistanceTransient ciliogenesis involving Bardet-Biedl syndrome proteins is a fundamental characteristic of adipogenic differentiation60 YEARS OF POMC: From POMC and α-MSH to PAM, molecular oxygen, copper, and vitamin CObesity genetics in mouse and human: back and forth, and back againControl of metabolic and cardiovascular function by the leptin-brain melanocortin pathwayLeptin signaling and leptin resistancePrimary cilia in the developing and mature brainUpdate on the genetics of bardet-biedl syndromeEctopic expression of human BBS4 can rescue Bardet-Biedl syndrome phenotypes in Bbs4 null miceAdult type 3 adenylyl cyclase-deficient mice are obeseThe nonmotile ciliopathies.Trafficking to the ciliary membrane: how to get across the periciliary diffusion barrier?Sympathetic nervous system overactivity and its role in the development of cardiovascular diseaseMagel2 is required for leptin-mediated depolarization of POMC neurons in the hypothalamic arcuate nucleus in miceLeptin resistance is a secondary consequence of the obesity in ciliopathy mutant miceID2 (inhibitor of DNA binding 2) is a rhythmically expressed transcriptional repressor required for circadian clock output in mouse liverCiliopathy is differentially distributed in the brain of a Bardet-Biedl syndrome mouse modelContrasting vascular effects caused by loss of Bardet-Biedl syndrome genes.Brain tissue- and region-specific abnormalities on volumetric MRI scans in 21 patients with Bardet-Biedl syndrome (BBS)Hyperactive neuroendocrine secretion causes size, feeding, and metabolic defects of C. elegans Bardet-Biedl syndrome mutants.Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagiaThe brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance.Eating behaviors in obese children with pseudohypoparathyroidism type 1a: a cross-sectional study.Inactivation of Bardet-Biedl syndrome genes causes kidney defects.Patients with Bardet-Biedl syndrome have hyperleptinemia suggestive of leptin resistance.Neuronal receptor activity-modifying protein 1 promotes energy expenditure in mice.Cardiovascular and sympathetic effects of disrupting tyrosine 985 of the leptin receptor.End stage renal disease, differential diagnosis, a rare genetic disorder: bardet-biedl syndrome: case report and review.Molecular basis of the obesity associated with Bardet-Biedl syndrome.BBS4 is necessary for ciliary localization of TrkB receptor and activation by BDNF.Leptin Elongates Hypothalamic Neuronal Cilia via Transcriptional Regulation and Actin DestabilizationThe BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane.Comparing the Bbs10 complete knockout phenotype with a specific renal epithelial knockout one highlights the link between renal defects and systemic inactivation in miceHypothalamic Leptin Resistance: From BBB to BBSome.
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P2860
Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome
description
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
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artículu científicu espublizáu en 2008
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im April 2008 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2008/04/01)
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vědecký článek publikovaný v roce 2008
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wetenschappelijk artikel (gepubliceerd op 2008/04/01)
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наукова стаття, опублікована у квітні 2008
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مقالة علمية (نشرت في أبريل 2008)
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name
Leptin resistance contributes ...... odels of Bardet-Biedl syndrome
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Leptin resistance contributes ...... odels of Bardet-Biedl syndrome
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Leptin resistance contributes ...... odels of Bardet-Biedl syndrome
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label
Leptin resistance contributes ...... odels of Bardet-Biedl syndrome
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Leptin resistance contributes ...... odels of Bardet-Biedl syndrome
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Leptin resistance contributes ...... odels of Bardet-Biedl syndrome
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prefLabel
Leptin resistance contributes ...... odels of Bardet-Biedl syndrome
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Leptin resistance contributes ...... odels of Bardet-Biedl syndrome
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Leptin resistance contributes ...... odels of Bardet-Biedl syndrome
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Leptin resistance contributes ...... odels of Bardet-Biedl syndrome
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Christopher J. Berry
Daniel R. Thedens
Darryl Y. Nishimura
Melissa A. Fath
Robert Weiss
Val C. Sheffield
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P304
P3181
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10.1172/JCI32357
P407
P577
2008-04-01T00:00:00Z