Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons - Wikidata - awgldk - TriplyDB

Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons

Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons

http://www.wikidata.org/entity/Q28511388

about

A protease-independent function for SPPL3 in NFAT activation The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration Early etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling.Familial dementia with frontotemporal features associated with M146V presenilin-1 mutation Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation.Dysregulation of protein trafficking in neurodegeneration.Increased accumulation of intraneuronal amyloid beta in HIV-infected patients.Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity.Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner.Pathological and physiological functions of presenilins.Autophagy failure in Alzheimer's disease--locating the primary defect.Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.The emerging role of proteolysis in mitochondrial quality control and the etiology of Parkinson's disease.The mechanism of γ-Secretase dysfunction in familial Alzheimer disease.Presenilins: a novel link between intracellular calcium signaling and lysosomal function?Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells.Acidic Ca2+ stores in neurodegeneration.Macroautophagy in sporadic and the genetic form of Parkinson's disease with the A53T α-synuclein mutation Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis.Constitutive autophagy: vital role in clearance of unfavorable proteins in neurons.Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death.Presenilin: RIP and beyond.TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau.Presenilin-1 acts via Id1 to regulate the function of muscle satellite cells in a gamma-secretase-independent manner.Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis.Cell "self-eating" (autophagy) mechanism in Alzheimer's disease.The very many faces of presenilins and the γ-secretase complex.Autophagy modulation for Alzheimer's disease therapy.Biological function of Presenilin and its role in AD pathogenesis Autophagy in Alzheimer's disease.Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification.Modulation of Autophagy as a Therapeutic Target for Alzheimer's Disease.

P2860

b39174054011ce158b6abe5b525707d215ae7213 d00dfa6021c7514164258bb54c736c99b568ed5b

P248

Q24306596-819CD82D-F5BC-4942-9B7F-4723B6E6414A Q24603159-E366CAA5-C350-4C97-9893-E23875D59DC8 Q24683089-FE2E36D4-C520-48DD-9BEB-64C5A106EBB0 Q27000356-88834ABD-1547-4C2E-9DBC-E43D3C7676A3 Q27026907-B948A6ED-39E8-49D7-BD02-1023EC9371E6 Q27693256-4CC756DE-7344-4CDA-ADC4-08D4E538E797 Q28506710-17AE9677-6A09-475C-95F3-7E4D7CFF1BD1 Q28591202-477D3440-7553-4665-9FC3-6FFDB53B2CD3 Q28591283-BDECE823-806A-4AD4-9857-70574DE65BBE Q30874655-44CD5A44-9232-437E-A8E3-4AC84B663967 Q33554860-CEE44BE7-DC4C-4B42-9A7F-DC89F1B31A9D Q34110227-D679BAA1-82D3-4666-80DF-303C40892D07 Q34249792-8D5A9D48-853C-4E20-85B2-E8AB47245377 Q34545170-090EC94F-E61D-4792-962C-BBA004F8FD62 Q34661343-DF2D6460-8BE9-4152-9CFC-5B44DD1CA2BA Q34684632-E2EBF832-958B-460A-9EF7-DA94CE27C551 Q34725167-8F66E100-9391-4B0B-84E8-C59ACD984714 Q34803524-0D1349B9-D2AA-4C46-BD57-8DCCE6D7D245 Q34987827-CA878A99-A03A-481A-A635-E5B4F2B1B063 Q35658184-68183135-3EF6-4974-A59D-5CA6686C8D7F Q35986574-DF4AF6E5-9459-43A6-B8BF-1373438B2F4D Q36000134-DA2C587A-20C9-41DB-8822-C1D0804A752D Q36085259-8C24621C-5D4D-46B8-B2D3-11D5E0F7E399 Q36085273-7B3CF8B2-C0CF-4799-A9EE-112F4FDD1C4D Q36395510-2EABC49D-2992-42CC-A4F0-6D701BDFB87A Q36424977-A4485991-549A-4660-A037-225DA6CF57F4 Q36513606-3088E021-E7AA-4E3C-BCFE-3508F510998B Q36749222-0DC101FF-4666-4A38-9002-08CAA330FB36 Q37040616-B0D37911-894A-47D4-87F3-B1C612ED36C6 Q37219819-BAD2B4F7-4E8A-49CE-AC82-22AC9E55722A Q37407659-308C1E41-7BD6-4A14-8651-FD891588955E Q37454742-B4B221A9-C2A4-4FAC-8BA5-724B868C9899 Q37679933-A435F28B-5272-413A-A030-EBD865566881 Q37681444-2C46FC47-8F52-4BE8-8C7C-E61DEDE0C276 Q38090514-4A0B8E70-C7BB-429B-ADEE-BD80806DCC2A Q38102606-311F5C40-B2FD-4241-ADE3-8903F0A9668A Q38122497-0088E42E-D19A-46AC-898F-A805C66804F5 Q38419936-93D56DBA-3A32-4AC7-8109-043C8CBC840A Q38841488-B54171B7-7FD2-4E41-A7E6-7F7039BA6F64 Q38911931-35D05BB3-27D2-45A0-8C02-AEC3EB9B0D3E

P2860

Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons

http://www.wikidata.org/entity/Q28511388

description

2004 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի մայիսին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2004

@ast

im Mai 2004 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2004/05/10)

@sk

vědecký článek publikovaný v roce 2004

@cs

wetenschappelijk artikel (gepubliceerd op 2004/05/10)

@nl

наукова стаття, опублікована в травні 2004

@uk

مقالة علمية (نشرت في 10-5-2004)

@ar

name

Degradative organelles contain ...... e in presenilin-1 null neurons

@ast

Degradative organelles contain ...... e in presenilin-1 null neurons

@en

Degradative organelles contain ...... e in presenilin-1 null neurons

@nl

type

label

Degradative organelles contain ...... e in presenilin-1 null neurons

@ast

Degradative organelles contain ...... e in presenilin-1 null neurons

@en

Degradative organelles contain ...... e in presenilin-1 null neurons

@nl

prefLabel

Degradative organelles contain ...... e in presenilin-1 null neurons

@ast

Degradative organelles contain ...... e in presenilin-1 null neurons

@en

Degradative organelles contain ...... e in presenilin-1 null neurons

@nl

P1433

Q28511388-15346C53-6A44-4666-B367-9C50339EAF80

P1476

Q28511388-9BF2BA94-C91B-473D-AD20-31DA35B453BC

P2093

Q28511388-06236D27-2C63-4166-8FBE-41CB3DCD834A

Q28511388-800A7008-CA52-4ADB-8702-21DBEBBC97AD

Q28511388-89AF45A8-8E5F-469F-92D1-5C4C5FC91452

Q28511388-8B49BE1F-4749-492C-B944-E3667B39C476

Q28511388-9D4C0FC8-CEA5-4582-889A-377E56B553CF

Q28511388-EDD7344C-726C-4C6A-8411-8A9F9A786628

P2860

Q28511388-0251D833-1B80-4A19-AA91-A86323EE3ABA

Q28511388-051DA513-F658-4977-BC7D-E706CFEAC707

Q28511388-07D90E8F-90C2-4517-9EFF-1D5FA6AC3222

Q28511388-0BDFE540-DDC0-48F0-9630-83B0106A9D41

Q28511388-0D3C89B3-8CFF-4BAB-B83F-40D846F7EE7E

Q28511388-0FE00D59-CCF7-4338-BF1F-914F8E152A00

Q28511388-111209F6-FB06-479C-AEA9-696BE519F9DD

Q28511388-1894AC26-C803-43B4-A7AD-25DB75B1526E

Q28511388-18D6F6F1-E968-44C8-AFFB-C8C1DDE15D2B

Q28511388-1AA11AC6-97FF-4731-B00D-1660051112B1

P304

Q28511388-9F97CA53-AED7-4F50-9CAB-8B134ECE92A4

P31

Q28511388-286938EA-5850-49FF-83F3-D2E241C9AFA9

P3181

Q28511388-DE9AEC29-CACE-459C-A708-2D4947DA8172

P356

Q28511388-D4ED6E12-B812-429D-AE1A-D04F44AC260F

P407

Q28511388-DFDD3B8B-BD2F-4DA2-9B57-7886F2174042

P433

Q28511388-F4EB1AC1-65DC-4D5C-966E-03279362DBB6

P478

Q28511388-B09BE594-E843-42D8-9C35-0B76AE9F496A

P577

Q28511388-BE557974-5AEE-4B65-964A-FD674D181493

P5875

Q28511388-4B3EB24A-167A-41AE-8359-7D89EC0BC2E4

P698

Q28511388-13335818-9172-419F-9B36-C8C249FF49AB

P921

Q28511388-34AC13BD-2B1A-40B7-9284-5BBDE7B9A40C

Q28511388-9832A337-A4A7-4E1D-A6E8-C47F746EC906

P932

Q28511388-28FF816F-377E-40E7-9917-6FEA5D2FD78E

P3181

P356

P1433

Journal of Cell Biology

P1476

Degradative organelles contain ...... e in presenilin-1 null neurons

@en

P2093

Benoit I. Giasson

http://www.w3.org/2001/XMLSchema#string

Bin Zhang

http://www.w3.org/2001/XMLSchema#string

Christina A. Wilson

http://www.w3.org/2001/XMLSchema#string

Diane D. Murphy

http://www.w3.org/2001/XMLSchema#string

John Q. Trojanowski

http://www.w3.org/2001/XMLSchema#string

Virginia M.-Y. Lee

http://www.w3.org/2001/XMLSchema#string

P2860

VAMP-7 mediates vesicular transport from endosomes to lysosomes

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits

A multispecificity syntaxin homologue, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole.

alpha-Synuclein shares physical and functional homology with 14-3-3 proteins

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway

Syntaxin 7 mediates endocytic trafficking to late endosomes

P304

335–346

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

2818728

http://www.w3.org/2001/XMLSchema#string

P356

10.1083/JCB.200403061

http://www.w3.org/2001/XMLSchema#string

P407

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

165

http://www.w3.org/2001/XMLSchema#string

P577

2004-05-10T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

8581311

http://www.w3.org/2001/XMLSchema#string

P698

15123735

http://www.w3.org/2001/XMLSchema#string

P921

P932

2172178

http://www.w3.org/2001/XMLSchema#string