Glycosylphosphatidylinositol-anchor-deficient mice: implications for clonal dominance of mutant cells in paroxysmal nocturnal hemoglobinuria
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Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteinsThe first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1.Glycosylphosphatidylinositol biosynthesis defects in Gpi11p- and Gpi13p-deficient yeast suggest a branched pathway and implicate gpi13p in phosphoethanolamine transfer to the third mannose.Modeling Human Bone Marrow Failure Syndromes Using Pluripotent Stem Cells and Genome EngineeringGPI-anchor synthesis is indispensable for the germline development of the nematode Caenorhabditis elegans.The genotypic and phenotypic spectrum of PIGA deficiency.Phenotypic and functional characterization of a mouse model of targeted Pig-a deletion in hematopoietic cellsIdentification of a species-specific inhibitor of glycosylphosphatidylinositol synthesis.Paroxysmal nocturnal haemoglobinuria: nature's gene therapy?Elevated levels of glycosylphosphatidylinositol (GPI) anchored proteins in plasma from human cancers detected by C. septicum alpha toxinParoxysmal nocturnal hemoglobinuriaMolecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH).The glycosylphosphatidylinositol anchor: a complex membrane-anchoring structure for proteins3'UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in mice.The phenotype of a germline mutation in PIGA: the gene somatically mutated in paroxysmal nocturnal hemoglobinuria.Genome-Wide Screening of Genes Required for Glycosylphosphatidylinositol Biosynthesis.pigk Mutation underlies macho behavior and affects Rohon-Beard cell excitability.Structural features affecting trafficking, processing, and secretion of Trypanosoma cruzi mucinsMicrovesicles/exosomes as potential novel biomarkers of metabolic diseasesA chemical approach to unraveling the biological function of the glycosylphosphatidylinositol anchor.Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individualsFES-Cre targets phosphatidylinositol glycan class A (PIGA) inactivation to hematopoietic stem cells in the bone marrowX inactivation and somatic cell selection rescue female mice carrying a Piga-null mutation.Uptake of radiolabeled GlcNAc into Saccharomyces cerevisiae via native hexose transporters and its in vivo incorporation into GPI precursors in cells expressing heterologous GlcNAc kinase.Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly.Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development.Potential link between MHC-self-peptide presentation and hematopoiesis; the analysis of HLA-DR expression in CD34-positive cells and self-peptide presentation repertoires of MHC molecules associated with paroxysmal nocturnal hemoglobinuria.GPI-AP release in cellular, developmental, and reproductive biology.Drosophila GPI-mannosyltransferase 2 is required for GPI anchor attachment and surface expression of chaoptin.Generation of glycosylphosphatidylinositol anchor protein-deficient blood cells from human induced pluripotent stem cellsImpaired growth and elevated fas receptor expression in PIGA(+) stem cells in primary paroxysmal nocturnal hemoglobinuriaGenetic and environmental effects in paroxysmal nocturnal hemoglobinuria: this little PIG-A goes "Why? Why? Why?"Murine embryonic stem cells without pig-a gene activity are competent for hematopoiesis with the PNH phenotype but not for clonal expansion.Caveolin-1 is not essential for biosynthetic apical membrane transport.BcCFEM1, a CFEM Domain-Containing Protein with Putative GPI-Anchored Site, Is Involved in Pathogenicity, Conidial Production, and Stress Tolerance in Botrytis cinerea.First step of glycosylphosphatidylinositol (GPI) biosynthesis cross-talks with ergosterol biosynthesis and Ras signaling in Candida albicans.CDG Therapies: From Bench to Bedside.Targeting the GPI biosynthetic pathway.Glycosylphosphatidylinositol (GPI)-deficient Jurkat T cells as a model to study functions of GPI-anchored proteins.
P2860
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P2860
Glycosylphosphatidylinositol-anchor-deficient mice: implications for clonal dominance of mutant cells in paroxysmal nocturnal hemoglobinuria
description
1996 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1996
@ast
im Mai 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/05/01)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/05/01)
@nl
наукова стаття, опублікована в травні 1996
@uk
مقالة علمية (نشرت في مايو 1996)
@ar
name
Glycosylphosphatidylinositol-a ...... ysmal nocturnal hemoglobinuria
@ast
Glycosylphosphatidylinositol-a ...... ysmal nocturnal hemoglobinuria
@en
Glycosylphosphatidylinositol-a ...... ysmal nocturnal hemoglobinuria
@nl
type
label
Glycosylphosphatidylinositol-a ...... ysmal nocturnal hemoglobinuria
@ast
Glycosylphosphatidylinositol-a ...... ysmal nocturnal hemoglobinuria
@en
Glycosylphosphatidylinositol-a ...... ysmal nocturnal hemoglobinuria
@nl
prefLabel
Glycosylphosphatidylinositol-a ...... ysmal nocturnal hemoglobinuria
@ast
Glycosylphosphatidylinositol-a ...... ysmal nocturnal hemoglobinuria
@en
Glycosylphosphatidylinositol-a ...... ysmal nocturnal hemoglobinuria
@nl
P2093
P1433
P1476
Glycosylphosphatidylinositol-a ...... ysmal nocturnal hemoglobinuria
@en
P2093
Kinoshita T
Kitamura D
Taniuchi I
Watanabe T
P304
P407
P577
1996-05-01T00:00:00Z