Murine embryonic stem cells without pig-a gene activity are competent for hematopoiesis with the PNH phenotype but not for clonal expansion.
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Modeling Human Bone Marrow Failure Syndromes Using Pluripotent Stem Cells and Genome EngineeringThe rate of spontaneous mutations in human myeloid cellsGPI-anchor synthesis is indispensable for the germline development of the nematode Caenorhabditis elegans.Phenotypic and functional characterization of a mouse model of targeted Pig-a deletion in hematopoietic cellsBiosynthesis of glycosylphosphatidylinositols in mammals and unicellular microbes.Implications of recent insights into the pathophysiology of paroxysmal nocturnal haemoglobinuria.Paroxysmal nocturnal haemoglobinuria: nature's gene therapy?Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethalThe mutational landscape of paroxysmal nocturnal hemoglobinuria revealed: new insights into clonal dominanceParoxysmal nocturnal hemoglobinuriaCytogenetic and morphological abnormalities in paroxysmal nocturnal haemoglobinuria.3'UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in mice.A new aspect of the molecular pathogenesis of paroxysmal nocturnal hemoglobinuria.An X chromosome gene regulates hematopoietic stem cell kinetics.Microvesicles/exosomes as potential novel biomarkers of metabolic diseasesClonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individualsLeukemic blasts with the paroxysmal nocturnal hemoglobinuria phenotype in children with acute lymphoblastic leukemia.FES-Cre targets phosphatidylinositol glycan class A (PIGA) inactivation to hematopoietic stem cells in the bone marrowX inactivation and somatic cell selection rescue female mice carrying a Piga-null mutation.Generation of glycosylphosphatidylinositol anchor protein-deficient blood cells from human induced pluripotent stem cellsImpaired growth and elevated fas receptor expression in PIGA(+) stem cells in primary paroxysmal nocturnal hemoglobinuriaThe in vitro PIG-A gene mutation assay: mutagenicity testing via flow cytometry based on the glycosylphosphatidylinositol (GPI) status of TK6 cells.Trophoblast differentiation defect in human embryonic stem cells lacking PIG-A and GPI-anchored cell-surface proteins.Compensatory erythropoiesis has no impact on the outcome of the in vivo Pig-a mutation assay in rats following treatment with the haemolytic agent 2-butoxyethanol.Paroxysmal nocturnal hemoglobinuria: pathophysiology, natural history and treatment options in the era of biological agents.Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins.Paroxysmal nocturnal hemoglobinuria and concurrent JAK2(V617F) mutation.Individual hematopoietic stem cells in human bone marrow of patients with aplastic anemia or myelodysplastic syndrome stably give rise to limited cell lineages.Chimaeric mice with disruption of the gene coding for phosphatidylinositol glycan class A (Pig-a) were defective in embryogenesis and spermatogenesis.Glycosylphosphatidylinositol (GPI)-deficient Jurkat T cells as a model to study functions of GPI-anchored proteins.
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Murine embryonic stem cells without pig-a gene activity are competent for hematopoiesis with the PNH phenotype but not for clonal expansion.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 1997
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Murine embryonic stem cells wi ...... but not for clonal expansion.
@en
Murine embryonic stem cells wi ...... but not for clonal expansion.
@nl
type
label
Murine embryonic stem cells wi ...... but not for clonal expansion.
@en
Murine embryonic stem cells wi ...... but not for clonal expansion.
@nl
prefLabel
Murine embryonic stem cells wi ...... but not for clonal expansion.
@en
Murine embryonic stem cells wi ...... but not for clonal expansion.
@nl
P2093
P2860
P356
P1476
Murine embryonic stem cells wi ...... e but not for clonal expansion
@en
P2093
P2860
P304
P356
10.1172/JCI119613
P407
P50
P577
1997-09-01T00:00:00Z