Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1.
about
Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communicationMeta-analysis of SHANK Mutations in Autism Spectrum Disorders: a gradient of severity in cognitive impairmentsSHANK1 Deletions in Males with Autism Spectrum DisorderImportance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapsesSynaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3Shank3 mutant mice display autistic-like behaviours and striatal dysfunctionThe 22q13.3 Deletion Syndrome (Phelan-McDermid Syndrome)Emerging pharmacotherapies for neurodevelopmental disordersDe novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia.Mechanisms of synapse and dendrite maintenance and their disruption in psychiatric and neurodegenerative disordersMultiple rare variants in the etiology of autism spectrum disordersKalirin-7 is required for synaptic structure and functionSynCAM 1 adhesion dynamically regulates synapse number and impacts plasticity and learning.Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders.Behavioral phenotypes of genetic mouse models of autism.Cellular and synaptic network defects in autismTherapeutic approaches for shankopathiesPharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.Overexpression of Homer1a in the basal and lateral amygdala impairs fear conditioning and induces an autism-like social impairmentActin-Dependent Alterations of Dendritic Spine Morphology in ShankopathiesNeuronal mechanisms and circuits underlying repetitive behaviors in mouse models of autism spectrum disorderSynaptopathies: synaptic dysfunction in neurological disorders - A review from students to studentsA Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disordersA new synaptic player leading to autism risk: Met receptor tyrosine kinaseAutistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2Evidence of cell-nonautonomous changes in dendrite and dendritic spine morphology in the met-signaling-deficient mouse forebrainEffect of social odor context on the emission of isolation-induced ultrasonic vocalizations in the BTBR T+tf/J mouse model for autism.Neuronal connectivity as a convergent target of gene × environment interactions that confer risk for Autism Spectrum DisordersKalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and functionLoose ligation of the rat sciatic nerve elicits early accumulation of Shank1 protein in the post-synaptic density of spinal dorsal horn neuronsDisassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathwaysShank1 mRNA: dendritic transport by kinesin and translational control by the 5'untranslated regionAssociation of mouse Dlg4 (PSD-95) gene deletion and human DLG4 gene variation with phenotypes relevant to autism spectrum disorders and Williams' syndromeCommunication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior.Sociability and motor functions in Shank1 mutant miceUsing Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autismModeling autistic features in animalsDegradation of postsynaptic scaffold GKAP and regulation of dendritic spine morphology by the TRIM3 ubiquitin ligase in rat hippocampal neuronsStriatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism.
P2860
Q21198697-938D3DD7-A3E0-4798-A4AF-1A9A0220A299Q23936599-128BE2FB-4F18-4488-8CAD-3C5E65C6042AQ24313471-89D00C9E-259B-40D9-9B42-D361C02B93E5Q24317227-0D6D1F54-18E7-4894-8AC8-7308EE99CA5CQ24596677-067BF084-3D0C-494B-8A65-FF129D828E2AQ24597501-7DE6BD51-24EA-47EA-B28D-64C45A60064DQ24612792-CC5F3B33-6519-4D62-BF05-171E95DEDE37Q24619170-45574716-C730-4983-8403-9186D44D35ADQ24621518-AB5D4292-15A6-489B-A4B2-B0D448153A3DQ24632757-B195D2F5-2AD4-456B-84B3-258822678442Q24635522-39EE84DE-039E-4C54-B40F-FA358763D1F3Q24654628-A7AD1F30-CB29-47CA-8282-93F44AB042FDQ26269902-60244248-18A9-4E5B-9B12-3DEE359D87DBQ26748761-CBD84932-68E6-4147-8465-D1FB6C9CF002Q26781456-2FD58F9B-9053-457C-973B-6A73032F163EQ26864843-EC6E37A7-B12A-4158-8D73-8C880DDC20C1Q27024976-412E8614-F573-4254-A274-A31DF04F301EQ27318675-0E7F51C3-210B-4E26-9538-874211C0C657Q27322939-097D0611-E208-41A9-A600-D9C4CC9571A6Q28066333-A3C019E6-BC8C-41AC-88C3-E6723F768BAEQ28071696-81D19CF7-0BE0-4F18-934E-258EF018178CQ28077671-5FCBDCEC-61F4-41D1-B42E-195EAF6B2DD2Q28079929-42BA36F5-7E85-487E-AF2D-7F2971EAED03Q28086869-3A00F123-9033-4890-8E02-7E7F6CF52A75Q28236081-E11EA62A-8790-4F09-A595-94D49169D508Q28268807-502B2ED1-8850-4E51-AE85-E15D1FA3F831Q28293701-8BA534D4-C80B-49C7-ABE1-869371A7D391Q28390065-AB65A1FC-A61A-4BF4-A817-B783D5B53273Q28396205-59F838EB-D2F7-46FB-9929-D5F856BB815CQ28509168-736AA6A4-2163-46C5-BC8C-69682BDC8720Q28574014-A781D2B3-D1E6-419B-B134-5AF3BC2A354BQ28575781-A890C397-38A4-4BF3-8C0A-DBDBE60B7FEEQ28583901-ADE425F1-CB5C-4453-8BF2-981DF0C172C7Q28586842-669FF0F9-DB32-4F3A-BF50-F9048EEBDEDFQ28592394-4C3794DE-B0BA-4D6F-8C42-E3A543C741EAQ28592494-757FEF02-7812-42B8-9CF1-AC044C89FA19Q28645671-2146AFC0-034D-49E1-88F9-213825014550Q28740448-E05DC261-6880-4362-AC96-E789FAB9FD26Q28748325-53D80B64-58AD-4AC0-9C33-E46E9F3E6B8BQ30008746-EFA050E0-BAF3-4C39-A7B9-C3992525BE9B
P2860
Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1.
description
2008 nî lūn-bûn
@nan
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Smaller dendritic spines, weak ...... earning in mice lacking Shank1
@nl
Smaller dendritic spines, weak ...... arning in mice lacking Shank1.
@ast
Smaller dendritic spines, weak ...... arning in mice lacking Shank1.
@en
type
label
Smaller dendritic spines, weak ...... earning in mice lacking Shank1
@nl
Smaller dendritic spines, weak ...... arning in mice lacking Shank1.
@ast
Smaller dendritic spines, weak ...... arning in mice lacking Shank1.
@en
prefLabel
Smaller dendritic spines, weak ...... earning in mice lacking Shank1
@nl
Smaller dendritic spines, weak ...... arning in mice lacking Shank1.
@ast
Smaller dendritic spines, weak ...... arning in mice lacking Shank1.
@en
P2093
P2860
P50
P3181
P1476
Smaller dendritic spines, weak ...... arning in mice lacking Shank1.
@en
P2093
Albert Y Hung
Clifford C Sung
Fleur L Kidd
Juli G Valtschanoff
Kensuke Futai
Mark F Bear
Morgan Sheng
P2860
P304
P3181
P356
10.1523/JNEUROSCI.3032-07.2008
P407
P577
2008-02-01T00:00:00Z