TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling - Wikidata - awgldk - TriplyDB

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

http://www.wikidata.org/entity/Q28513445

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Biology of RANK, RANKL, and osteoprotegerin TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network T6BP, a TRAF6-interacting protein involved in IL-1 signaling CIKS, a connection to Ikappa B kinase and stress-activated protein kinase CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6 Structure and functional properties of the ubiquitin binding protein p62 Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesis Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling TAB3, a new binding partner of the protein kinase TAK1 TRAF6-deficient mice display hypohidrotic ectodermal dysplasia.Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice.Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6 Stress-induced decrease in TRAF2 stability is mediated by Siah2 MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice RANK is essential for osteoclast and lymph node development MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK)Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation Tumor necrosis factor receptor-associated factor 6 is an intranuclear transcriptional coactivator in osteoclasts The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL Osteoimmunology: interactions of the bone and immune system Molecular basis for CD40 signaling mediated by TRAF3 Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction

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TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

http://www.wikidata.org/entity/Q28513445

description

1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 1999

@ast

im April 1999 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 1999/04/15)

@sk

vědecký článek publikovaný v roce 1999

@cs

wetenschappelijk artikel (gepubliceerd op 1999/04/15)

@nl

наукова стаття, опублікована у квітні 1999

@uk

مقالة علمية (نشرت في 15-4-1999)

@ar

name

TRAF6 deficiency results in os ...... kin-1, CD40, and LPS signaling

@ast

TRAF6 deficiency results in os ...... kin-1, CD40, and LPS signaling

@en

TRAF6 deficiency results in os ...... kin-1, CD40, and LPS signaling

@nl

type

label

TRAF6 deficiency results in os ...... kin-1, CD40, and LPS signaling

@ast

TRAF6 deficiency results in os ...... kin-1, CD40, and LPS signaling

@en

TRAF6 deficiency results in os ...... kin-1, CD40, and LPS signaling

@nl

prefLabel

TRAF6 deficiency results in os ...... kin-1, CD40, and LPS signaling

@ast

TRAF6 deficiency results in os ...... kin-1, CD40, and LPS signaling

@en

TRAF6 deficiency results in os ...... kin-1, CD40, and LPS signaling

@nl

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Genes & Development

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TRAF6 deficiency results in os ...... kin-1, CD40, and LPS signaling

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A Ho

http://www.w3.org/2001/XMLSchema#string

A Itie

http://www.w3.org/2001/XMLSchema#string

A Wakeham

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A van der Heiden

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C Capparelli

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C Furlonger

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C J Paige

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D L Lacey

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D V Goeddel

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G S Duncan

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P2860

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Involvement of CRAF1, a relative of TRAF, in CD40 signaling

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5

IRAK: a kinase associated with the interleukin-1 receptor

Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1

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1015-1024

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692533

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10.1101/GAD.13.8.1015

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8

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13

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Josef M Penninger

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13082020

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10215628

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TNF receptor-associated factor 6

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316636

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