In vitro and in vivo evaluation of cysteine and site specific conjugated herceptin antibody-drug conjugates
about
Antibody drug conjugates: design and selection of linker, payload and conjugation chemistryStability analysis of an inline peptide-based conjugate for metal delivery: nickel(II)-claMP Tag epidermal growth factor as a model system.Design of S-Allylcysteine in Situ Production and Incorporation Based on a Novel Pyrrolysyl-tRNA Synthetase Variant.Evaluation of Factors Influencing Antibody Reduction for Development of Antibody Drug ConjugatesImproving the serum stability of site-specific antibody conjugates with sulfone linkers.Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomesMultiformat T-cell-engaging bispecific antibodies targeting human breast cancers.Antibody Drug Conjugates: Nonclinical Safety Considerations.Therapeutic applications of an expanded genetic code.Using the Lessons Learned From the Clinic to Improve the Preclinical Development of Antibody Drug ConjugatesNew horizons in therapeutic antibody discovery: opportunities and challenges versus small-molecule therapeutics.Application of Pharmacokinetic-Pharmacodynamic Modeling and Simulation for Antibody-Drug Conjugate Development.Stable and Potent Selenomab-Drug Conjugates.Antibody Drug Conjugates: Application of Quantitative Pharmacology in Modality Design and Target Selection.Integration of bioanalytical measurements using PK-PD modeling and simulation: implications for antibody-drug conjugate development.In vivo biotransformations of antibody-drug conjugates.Towards the next generation of biomedicines by site-selective conjugation.Multiscale Modeling of Antibody-Drug Conjugates: Connecting Tissue and Cellular Distribution to Whole Animal Pharmacokinetics and Potential Implications for Efficacy.Strategies and challenges for the next generation of antibody-drug conjugates.Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugatesImproved Tumor Penetration and Single-Cell Targeting of Antibody Drug Conjugates Increases Anticancer Efficacy and Host Survival.Molecular engineering of antibodies for site-specific covalent conjugation using CRISPR/Cas9.Progress in biopharmaceutical development.Influence of disulfide bond isoforms on drug conjugation sites in cysteine-linked IgG2 antibody-drug conjugates.Site-Specific Antibody Conjugation for ADC and Beyond.ADME for Therapeutic Biologics: Antibody-Derived Proteins and Proteins with Novel Scaffolds
P2860
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P2860
In vitro and in vivo evaluation of cysteine and site specific conjugated herceptin antibody-drug conjugates
description
2014 nî lūn-bûn
@nan
2014 թուականին հրատարակուած գիտական յօդուած
@hyw
2014 թվականին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
In vitro and in vivo evaluatio ...... eptin antibody-drug conjugates
@ast
In vitro and in vivo evaluatio ...... eptin antibody-drug conjugates
@en
In vitro and in vivo evaluatio ...... eptin antibody-drug conjugates
@nl
type
label
In vitro and in vivo evaluatio ...... eptin antibody-drug conjugates
@ast
In vitro and in vivo evaluatio ...... eptin antibody-drug conjugates
@en
In vitro and in vivo evaluatio ...... eptin antibody-drug conjugates
@nl
prefLabel
In vitro and in vivo evaluatio ...... eptin antibody-drug conjugates
@ast
In vitro and in vivo evaluatio ...... eptin antibody-drug conjugates
@en
In vitro and in vivo evaluatio ...... eptin antibody-drug conjugates
@nl
P2093
P2860
P1433
P1476
In vitro and in vivo evaluatio ...... eptin antibody-drug conjugates
@en
P2093
Aaron Sellers
Anthony Manibusan
Banmeet Anand
Christine Lowe
Chunying Zhang
Claudia I Guevara
Cyrus Virata
Daniel S Pereira
David Stover
Dowdy Jackson
P2860
P304
P356
10.1371/JOURNAL.PONE.0083865
P407
P577
2014-01-01T00:00:00Z