Application of Pharmacokinetic-Pharmacodynamic Modeling and Simulation for Antibody-Drug Conjugate Development.
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Chemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug ConjugatesEvolution of Antibody-Drug Conjugate Tumor Disposition Model to Predict Preclinical Tumor Pharmacokinetics of Trastuzumab-Emtansine (T-DM1).Determination of Cellular Processing Rates for a Trastuzumab-Maytansinoid Antibody-Drug Conjugate (ADC) Highlights Key Parameters for ADC Design.Pharmacokinetic and pharmacodynamic considerations for the next generation protein therapeutics.Measurement and Mathematical Characterization of Cell-Level Pharmacokinetics of Antibody-Drug Conjugates: A Case Study with Trastuzumab-vc-MMAE.Development of a Translational Physiologically Based Pharmacokinetic Model for Antibody-Drug Conjugates: a Case Study with T-DM1.Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper.Multiscale Modeling of Antibody-Drug Conjugates: Connecting Tissue and Cellular Distribution to Whole Animal Pharmacokinetics and Potential Implications for Efficacy.Application of a PK-PD Modeling and Simulation-Based Strategy for Clinical Translation of Antibody-Drug Conjugates: a Case Study with Trastuzumab Emtansine (T-DM1).A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim.Calculated conjugated payload from immunoassay and LC-MS intact protein analysis measurements of antibody-drug conjugate.Antibody-conjugated drug assay for protease-cleavable antibody-drug conjugates.
P2860
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P2860
Application of Pharmacokinetic-Pharmacodynamic Modeling and Simulation for Antibody-Drug Conjugate Development.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
Application of Pharmacokinetic ...... dy-Drug Conjugate Development.
@en
type
label
Application of Pharmacokinetic ...... dy-Drug Conjugate Development.
@en
prefLabel
Application of Pharmacokinetic ...... dy-Drug Conjugate Development.
@en
P2860
P1476
Application of Pharmacokinetic ...... dy-Drug Conjugate Development.
@en
P2093
Aman P Singh
Dhaval K Shah
P2860
P304
P356
10.1007/S11095-015-1626-1
P50
P577
2015-02-11T00:00:00Z