Inhibition of c-Myc overcomes cytotoxic drug resistance in acute myeloid leukemia cells by promoting differentiation
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Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids.Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia.Antiproliferative effect of ZSTK474 alone or in combination with chemotherapeutic drugs on HL60 and HL60/ADR cellsNovel agent nitidine chloride induces erythroid differentiation and apoptosis in CML cells through c-Myc-miRNAs axis.Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formationMicroRNA-181a enhances the chemotherapeutic sensitivity of chronic myeloid leukemia to imatinib.The hypomethylating agent decitabine prior to chemotherapy improves the therapy efficacy in refractory/relapsed acute myeloid leukemia patients.Inhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells.Aurora A Kinase Inhibitor AKI603 Induces Cellular Senescence in Chronic Myeloid Leukemia Cells Harboring T315I Mutation.HA117 endows HL60 cells with a stem-like signature by inhibiting the degradation of DNMT1 via its ability to down-regulate expression of the GGL domain of RGS6Inhibition of cell survival and proliferation by nimbolide in human androgen-independent prostate cancer (PC-3) cells: involvement of the PI3K/Akt pathway.c-Myc-miR-29c-REV3L signalling pathway drives the acquisition of temozolomide resistance in glioblastoma.Role of micro-RNAs in drug resistance of multiple myeloma.Vitamin K2 and cotylenin A synergistically induce monocytic differentiation and growth arrest along with the suppression of c-MYC expression and induction of cyclin G2 expression in human leukemia HL-60 cells.A positive feedback loop involving the Wnt/β-catenin/MYC/Sox2 axis defines a highly tumorigenic cell subpopulation in ALK-positive anaplastic large cell lymphomaShikonin suppresses proliferation and induces apoptosis in human leukemia NB4 cells through modulation of MAPKs and c‑Myc.Repression of oxidative phosphorylation sensitizes leukemia cell lines to cytarabine.Heteronemin, a marine natural product, sensitizes acute myeloid leukemia cells towards cytarabine chemotherapy by regulating farnesylation of Ras.The Bromodomain Inhibitor JQ1 Enhances the Responses to All-trans Retinoic Acid in HL-60 and MV4-11 Leukemia Cells.The Myc/Max/Mxd Network Is a Target of Mutated Flt3 Signaling in Hematopoietic Stem Cells in Flt3-ITD-Induced Myeloproliferative Disease
P2860
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P2860
Inhibition of c-Myc overcomes cytotoxic drug resistance in acute myeloid leukemia cells by promoting differentiation
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2014 nî lūn-bûn
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2014 թուականին հրատարակուած գիտական յօդուած
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2014 թվականին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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name
Inhibition of c-Myc overcomes ...... s by promoting differentiation
@ast
Inhibition of c-Myc overcomes ...... s by promoting differentiation
@en
Inhibition of c-Myc overcomes ...... s by promoting differentiation
@nl
type
label
Inhibition of c-Myc overcomes ...... s by promoting differentiation
@ast
Inhibition of c-Myc overcomes ...... s by promoting differentiation
@en
Inhibition of c-Myc overcomes ...... s by promoting differentiation
@nl
prefLabel
Inhibition of c-Myc overcomes ...... s by promoting differentiation
@ast
Inhibition of c-Myc overcomes ...... s by promoting differentiation
@en
Inhibition of c-Myc overcomes ...... s by promoting differentiation
@nl
P2093
P2860
P3181
P1433
P1476
Inhibition of c-Myc overcomes ...... s by promoting differentiation
@en
P2093
Dong-Jun Lin
Jia-Jie Chen
Le-Xun Wang
Ling-Ling Liu
Quentin Liu
Ruo-Zhi Xiao
Xiao-Na Pan
Zhi-Gang Fang
Zi-Jie Long
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0105381
P407
P577
2014-01-01T00:00:00Z