Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization

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AFM Imaging Reveals Topographic Diversity of Wild Type and Z Variant Polymers of Human α1-Proteinase Inhibitor Liver Disease in Alpha-1 Antitrypsin Deficiency: Current Approaches and Future Directions.

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Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization

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2015 թվականին հրատարակված գիտական հոդված

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2015年論文

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2015年論文

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2015年論文

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Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization

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Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization

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Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization

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Item

label

Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization

@ast

Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization

@en

Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization

@nl

prefLabel

Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization

@ast

Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization

@en

Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization

@nl

P1476

Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization

@en

P2093

Jason Brett Harris

http://www.w3.org/2001/XMLSchema#string

Jerome Baudry

http://www.w3.org/2001/XMLSchema#string

Kasey Noel Estenson

http://www.w3.org/2001/XMLSchema#string

Valerie Berthelier

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P2860

Intravenous alpha-1 antitrypsin augmentation therapy for treating patients with alpha-1 antitrypsin deficiency and lung disease

Structure of a serpin-protease complex shows inhibition by deformation

Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer

Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates

Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease

Topography of a 2.0 Å structure of α1-antitrypsin reveals targets for rational drug design to prevent conformational disease

Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding

Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization

Crystallographic and Cellular Characterisation of Two Mechanisms Stabilising the Native Fold of α1-Antitrypsin: Implications for Disease and Drug Design

Ensemble-based virtual screening reveals potential novel antiviral compounds for avian influenza neuraminidase.

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scholarly article

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10.1371/JOURNAL.PONE.0126256

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English

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2015-01-01T00:00:00Z

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25961288

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4427445

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Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization

about

P2860

P2860

Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P3181

P356

P407

P433

P478

P577

P5875

P698

P932

P3181

P356

P1433

P1476

P2093

P2860

P304

P31

P3181

P356

P407

P433

P478

P577

P5875

P698

P932