AFM Imaging Reveals Topographic Diversity of Wild Type and Z Variant Polymers of Human α1-Proteinase Inhibitor

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The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization.Recent advances in hybrid measurement methods based on atomic force microscopy and surface sensitive measurement techniques

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AFM Imaging Reveals Topographic Diversity of Wild Type and Z Variant Polymers of Human α1-Proteinase Inhibitor

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2016 nî lūn-bûn

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2016 թուականին հրատարակուած գիտական յօդուած

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2016 թվականին հրատարակված գիտական հոդված

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2016年の論文

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2016年論文

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AFM Imaging Reveals Topographi ...... Human α1-Proteinase Inhibitor

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AFM Imaging Reveals Topographi ...... Human α1-Proteinase Inhibitor

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AFM Imaging Reveals Topographi ...... Human α1-Proteinase Inhibitor

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AFM Imaging Reveals Topographi ...... Human α1-Proteinase Inhibitor

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AFM Imaging Reveals Topographi ...... Human α1-Proteinase Inhibitor

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AFM Imaging Reveals Topographi ...... Human α1-Proteinase Inhibitor

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AFM Imaging Reveals Topographi ...... Human α1-Proteinase Inhibitor

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AFM Imaging Reveals Topographi ...... Human α1-Proteinase Inhibitor

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AFM Imaging Reveals Topographi ...... Human α1-Proteinase Inhibitor

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AFM Imaging Reveals Topographi ...... Human α1-Proteinase Inhibitor

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Christine E Stuart

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Ewa Marszal

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Malgorzata G Norton

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Maria Gaczynska

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P2860

Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer

Topography of a 2.0 Å structure of α1-antitrypsin reveals targets for rational drug design to prevent conformational disease

A structural basis for loop C-sheet polymerization in serpins

Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization

Crystallographic and Cellular Characterisation of Two Mechanisms Stabilising the Native Fold of α1-Antitrypsin: Implications for Disease and Drug Design

The 2.1-A crystal structure of native neuroserpin reveals unique structural elements that contribute to conformational instability

Biological implications of a 3 A structure of dimeric antithrombin

Serpin structure, mechanism, and function

Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization

3V: cavity, channel and cleft volume calculator and extractor.

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e0151902

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scholarly article

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10.1371/JOURNAL.PONE.0151902

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Pawel A. Osmulski

Jeffrey Teckman

Przemyslaw Karpowicz

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2016-03-23T00:00:00Z

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299396014

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27008547

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AFM Imaging Reveals Topographic Diversity of Wild Type and Z Variant Polymers of Human α1-Proteinase Inhibitor

about

P2860

P2860

AFM Imaging Reveals Topographic Diversity of Wild Type and Z Variant Polymers of Human α1-Proteinase Inhibitor

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