Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis - Wikidata - awgldk - TriplyDB

Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis

Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis

http://www.wikidata.org/entity/Q28551227

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Fundamentals of cancer metabolism Unexploited Antineoplastic Effects of Commercially Available Anti-Diabetic Drugs Medium Renewal Blocks Anti-Proliferative Effects of Metformin in Cultured MDA-MB-231 Breast Cancer Cells Combined treatment with Metformin and 2-deoxy glucose induces detachment of viable MDA-MB-231 breast cancer cells in vitro.Metformin inhibited esophageal squamous cell carcinoma proliferation in vitro and in vivo and enhanced the anti-cancer effect of cisplatin Activation of AMPKα mediates additive effects of solamargine and metformin on suppressing MUC1 expression in castration-resistant prostate cancer cells Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis: evidence for metformin-based "starvation" strategies in BRCA1 carriers.Suppression of endogenous lipogenesis induces reversion of the malignant phenotype and normalized differentiation in breast cancer.Caffeic Acid Expands Anti-Tumor Effect of Metformin in Human Metastatic Cervical Carcinoma HTB-34 Cells: Implications of AMPK Activation and Impairment of Fatty Acids De Novo Biosynthesis.Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models.Pharmacological Management of Gestational Diabetes Mellitus.Combined transcriptome and metabolome analyses of metformin effects reveal novel links between metabolic networks in steroidogenic systems.An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer.Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers.Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin.Combinational strategies of metformin and chemotherapy in cancers.Metformin in pancreatic cancer treatment: from clinical trials through basic research to biomarker quantification.One-Carbon Metabolism in Health and Disease.A spatiotemporal hypothesis for the regulation, role, and targeting of AMPK in prostate cancer.MYC and AMPK-Save Energy or Die!Regulation of organelle function by metformin.The diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respiration.Metformin Inhibits TGF-β1-Induced Epithelial-to-Mesenchymal Transition via PKM2 Relative-mTOR/p70s6k Signaling Pathway in Cervical Carcinoma Cells.Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism.Metformin inhibits SUV39H1-mediated migration of prostate cancer cells.Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials.Cancer: Linking Powerhouses to Suicidal Bags.Pleiotropic Effects of Biguanides on Mitochondrial Reactive Oxygen Species Production.Metformin targets histone acetylation in cancer-prone epithelial cells.Impaired mitochondrial functions contribute to 3-bromopyruvate toxicity in primary rat and mouse hepatocytes.Metabolomic mapping of cancer stem cells for reducing and exploiting tumor heterogeneity.Fixed-Dose Combinations of Pioglitazone and Metformin for Lung Cancer Prevention.Metformin Potentiates the Benefits of Dietary Restraint: A Metabolomic Study.Mitochondrial DNA, nuclear context, and the risk for carcinogenesis.Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells.Metformin synergistically suppress tumor growth with doxorubicin and reverse drug resistance by inhibiting the expression and function of P-glycoprotein in MCF7/ADR cells and xenograft models.Fatty acid synthase (FASN) as a therapeutic target in breast cancer.Metformin adapts its cellular effects to bioenergetic status in a model of metabolic dysfunction.Impact of diabetes mellitus on the risk and survival of nasopharyngeal carcinoma: a meta-analysis.Metabolic changes associated with metformin potentiates Bcl-2 inhibitor, Venetoclax, and CDK9 inhibitor, BAY1143572 and reduces viability of lymphoma cells.

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Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis

http://www.wikidata.org/entity/Q28551227

description

2015 nî lūn-bûn

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2015 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

Metformin Antagonizes Cancer C ...... ondrial-Dependent Biosynthesis

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Metformin Antagonizes Cancer C ...... ondrial-Dependent Biosynthesis

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Metformin Antagonizes Cancer C ...... ondrial-Dependent Biosynthesis

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Metformin Antagonizes Cancer C ...... ondrial-Dependent Biosynthesis

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Metformin Antagonizes Cancer C ...... ondrial-Dependent Biosynthesis

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Metformin Antagonizes Cancer C ...... ondrial-Dependent Biosynthesis

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Metformin Antagonizes Cancer C ...... ondrial-Dependent Biosynthesis

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Metformin Antagonizes Cancer C ...... ondrial-Dependent Biosynthesis

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Metformin Antagonizes Cancer C ...... ondrial-Dependent Biosynthesis

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Metformin Antagonizes Cancer C ...... ondrial-Dependent Biosynthesis

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Jocelyn Chen

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Ralph J DeBerardinis

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Robert Egnatchik

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Russell G Jones

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P2860

Role of AMP-activated protein kinase in mechanism of metformin action

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Brick by brick: metabolism and tumor cell growth

Investigating metformin for cancer prevention and treatment: the end of the beginning

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Metformin as an adjuvant drug against pediatric sarcomas: hypoxia limits therapeutic effects of the drug

Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

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10.1371/JOURNAL.PBIO.1002309

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Brandon Faubert

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