Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes
about
Complexin controls the force transfer from SNARE complexes to membranes in fusionMunc18-1 binding to the neuronal SNARE complex controls synaptic vesicle primingRIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13The dynamic architecture of photoreceptor ribbon synapses: cytoskeletal, extracellular matrix, and intramembrane proteinsDistinct initial SNARE configurations underlying the diversity of exocytosisModular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short-term synaptic plasticityThe Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering FactorsRegulation of exocytosis by the exocyst subunit Sec6 and the SM protein Sec1.A novel Dutch mutation in UNC13D reveals an essential role of the C2B domain in munc13-4 functionCAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosisMunc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complexReconstituting SNARE-mediated membrane fusion at the single liposome level.Single-molecule studies of the neuronal SNARE fusion machinery.Real-time visualization of complexin during single exocytic events.BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cellsMembrane bridging and hemifusion by denaturated Munc18.At the junction of SNARE and SM protein function.Involvement of Rab3A in vesicle priming during exocytosis: interaction with Munc13-1 and Munc18-1.Low-resolution solution structures of Munc18:Syntaxin protein complexes indicate an open binding mode driven by the Syntaxin N-peptide.Novel interactions of CAPS (Ca2+-dependent activator protein for secretion) with the three neuronal SNARE proteins required for vesicle fusion.Reluctance to membrane binding enables accessibility of the synaptobrevin SNARE motif for SNARE complex formationDiacylglycerol signaling underlies astrocytic ATP releaseBinding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion.Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission.Two-photon fluorescence lifetime imaging of primed SNARE complexes in presynaptic terminals and β cellsEnlightening molecular mechanisms through study of protein interactionsComplexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system.Synaptic vesicle fusion.Munc18a scaffolds SNARE assembly to promote membrane fusionUNC-18 modulates ethanol sensitivity in Caenorhabditis elegans.Functional synergy between the Munc13 C-terminal C1 and C2 domains.Reconstitution of the vital functions of Munc18 and Munc13 in neurotransmitter release.Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic stateMonitoring anthrax toxin receptor dissociation from the protective antigen by NMRRescuing the subprime meltdown in insulin exocytosis in diabetes.CAPS drives trans-SNARE complex formation and membrane fusion through syntaxin interactionsTilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis.Role of vesicle tethering factors in the ER-Golgi membrane traffic.Platelet signaling-a primer.
P2860
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P2860
Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes
description
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im Februar 2008 veröffentlicher wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/02/12)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/02/12)
@nl
наукова стаття, опублікована в лютому 2008
@uk
مقالة علمية (نشرت في 12-2-2008)
@ar
name
Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes
@ast
Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes
@en
Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes
@nl
type
label
Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes
@ast
Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes
@en
Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes
@nl
prefLabel
Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes
@ast
Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes
@en
Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes
@nl
P3181
P356
P1433
P1476
Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes
@en
P2093
P304
P3181
P356
10.1021/BI702345M
P407
P50
P577
2008-02-12T00:00:00Z