CAPS drives trans-SNARE complex formation and membrane fusion through syntaxin interactions
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Phosphoinositides: tiny lipids with giant impact on cell regulationResident CAPS on dense-core vesicles docks and primes vesicles for fusionThe Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering FactorsMunc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complexCAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neuronsSNAREpin assembly by Munc18-1 requires previous vesicle docking by synaptotagmin 1.Reconstituting SNARE-mediated membrane fusion at the single liposome level.Phosphatidylinositol 4,5-bisphosphate alters synaptotagmin 1 membrane docking and drives opposing bilayers closer together.Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers.Syntaxin clusters assemble reversibly at sites of secretory granules in live cells.Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network.Docking, not fusion, as the rate-limiting step in a SNARE-driven vesicle fusion assayHOPS initiates vacuole docking by tethering membranes before trans-SNARE complex assembly.SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion.Novel interactions of CAPS (Ca2+-dependent activator protein for secretion) with the three neuronal SNARE proteins required for vesicle fusion.Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion.Reconstituting Intracellular Vesicle Fusion Reactions: The Essential Role of Macromolecular CrowdingThe trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosisPRIP (phospholipase C-related but catalytically inactive protein) inhibits exocytosis by direct interactions with syntaxin 1 and SNAP-25 through its C2 domain.CAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3-CA1 synapses in adult hippocampusThe Vesicle Priming Factor CAPS Functions as a Homodimer via C2 Domain Interactions to Promote Regulated Vesicle Exocytosis.CAPS1 Negatively Regulates Hepatocellular Carcinoma Development through Alteration of Exocytosis-Associated Tumor Microenvironment.CAPS1 RNA Editing Promotes Dense Core Vesicle ExocytosisSystematizing and cloning of genes involved in the cerebellar cortex circuit development.Role of PI(4,5)P(2) in vesicle exocytosis and membrane fusion.CAPS and Munc13: CATCHRs that SNARE VesiclesPI(4,5)P₂-binding effector proteins for vesicle exocytosis.Planar Supported Membranes with Mobile SNARE Proteins and Quantitative Fluorescence Microscopy Assays to Study Synaptic Vesicle FusionMunc13 homology domain-1 in CAPS/UNC31 mediates SNARE binding required for priming vesicle exocytosis.Phosphatidylinositol 4,5-bisphosphate regulation of SNARE function in membrane fusion mediated by CAPS.Calcium-dependent activator protein for secretion 1 (CAPS1) binds to syntaxin-1 in a distinct mode from Munc13-1.Two distinct secretory vesicle-priming steps in adrenal chromaffin cellsSynaptobrevin N-terminally bound to syntaxin-SNAP-25 defines the primed vesicle state in regulated exocytosisPhosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis.Small molecules that inhibit the late stage of Munc13-4-dependent secretory granule exocytosis in mast cells.
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CAPS drives trans-SNARE complex formation and membrane fusion through syntaxin interactions
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 29 September 2009
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vetenskaplig artikel
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videnskabelig artikel
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CAPS drives trans-SNARE comple ...... through syntaxin interactions
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CAPS drives trans-SNARE comple ...... through syntaxin interactions.
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CAPS drives trans-SNARE comple ...... through syntaxin interactions
@en
CAPS drives trans-SNARE comple ...... through syntaxin interactions.
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prefLabel
CAPS drives trans-SNARE comple ...... through syntaxin interactions
@en
CAPS drives trans-SNARE comple ...... through syntaxin interactions.
@nl
P2093
P2860
P356
P1476
CAPS drives trans-SNARE comple ...... through syntaxin interactions
@en
P2093
Declan J James
Judith Kowalchyk
Matt Petrie
Neil Daily
Thomas F J Martin
P2860
P304
17308-17313
P356
10.1073/PNAS.0900755106
P407
P577
2009-09-29T00:00:00Z