Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes
about
Assessing Concordance of Drug-Induced Transcriptional Response in Rodent Liver and Cultured HepatocytesSynergistic effects of glycated chitosan with high-intensity focused ultrasound on suppression of metastases in a syngeneic breast tumor modelToxicogenomics directory of chemically exposed human hepatocytes.Biomarker: the universe of chemically induced gene expression alterations in human hepatocytePerspectives of tissues in silicoRecent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Modeling bioavailability to organs protected by biological barriers.Hepatotoxicity of piperazine designer drugs: up-regulation of key enzymes of cholesterol and lipid biosynthesis.The importance of protein binding for the in vitro-in vivo extrapolation (IVIVE)-example of ibuprofen, a highly protein-bound substance.In vitro test systems and their limitations.Transcriptomics in developmental toxicity testing.Advances in 2D and 3D in vitro systems for hepatotoxicity testing.Highlight report: Software for tissue analysis and reconstruction.Concepts of predictive toxicology.Quantification of three-dimensional structures in liver tissue: bile canalicular and sinusoidal networks.Possibilities and limitations of intravital imaging.The body-on-a-chip concept: possibilities and limitationsIntegrated spatiotemporal-metabolic modelling bridges the gap between metabolism on the cellular level and organ function.Toxicology: a discipline in need of academic anchoring--the point of view of the German Society of Toxicology.A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens.Recent developments in animal sciences.Highlight report: Interspecies extrapolation by physiologically based pharmacokinetic modeling.Recent developments in in vitro toxicology: perspectives of European research and Tox21.Highlight report: biomarkers of acetaminophen-induced liver injury.Highlight report: xenobiotic-metabolizing enzymes in skin models.Current research on experimental and applied animal sciences.In vitro systems: current limitations and future perspectives.The virtual liver: state of the art and future perspectives.Progress in 'body-on-a-chip' research.Highlight report: acetaminophen hepatotoxicity.Perspectives in toxicologic pathology: quantification of bile canalicular networks.
P2860
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P2860
Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes
description
2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2013
@ast
im Februar 2013 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2013/02/01)
@sk
vědecký článek publikovaný v roce 2013
@cs
wetenschappelijk artikel (gepubliceerd op 2013/02/01)
@nl
наукова стаття, опублікована в лютому 2013
@uk
مقالة علمية (نشرت في فبراير 2013)
@ar
name
Pharmacokinetics explain in vi ...... ver and cultivated hepatocytes
@ast
Pharmacokinetics explain in vi ...... ver and cultivated hepatocytes
@en
Pharmacokinetics explain in vi ...... ver and cultivated hepatocytes
@nl
type
label
Pharmacokinetics explain in vi ...... ver and cultivated hepatocytes
@ast
Pharmacokinetics explain in vi ...... ver and cultivated hepatocytes
@en
Pharmacokinetics explain in vi ...... ver and cultivated hepatocytes
@nl
prefLabel
Pharmacokinetics explain in vi ...... ver and cultivated hepatocytes
@ast
Pharmacokinetics explain in vi ...... ver and cultivated hepatocytes
@en
Pharmacokinetics explain in vi ...... ver and cultivated hepatocytes
@nl
P2093
P2860
P50
P3181
P1476
Pharmacokinetics explain in vi ...... ver and cultivated hepatocytes
@en
P2093
Andreas Nüssler
Georgia Günther
Hans-Jürgen Ahr
Heidrun Ellinger-Ziegelbauer
Jan G. Hengstler
Markus Schug
Meinolf Blaszkewicz
Patricio Godoy
Raymond Reif
Regina Stöber
P2860
P2888
P304
P3181
P356
10.1007/S00204-012-0999-8
P577
2013-02-01T00:00:00Z
P5875
P6179
1009179889