Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells
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Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytesRhoA regulation of NF-kappaB activation is mediated by COX-2-dependent feedback inhibition of IKK in kidney epithelial cellsTargeting protein prenylation for cancer therapyInduction of inducible nitric oxide synthase-NO* by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK1-ERK, MKK7-JNK, and NF-kappaB signaling pathways.Isoprenoids and related pharmacological interventions: potential application in Alzheimer's disease.Diabetes-induced increased oxidative stress in cardiomyocytes is sustained by a positive feedback loop involving Rho kinase and PKCβ2.Regulation of smooth muscle by inducible nitric oxide synthase and NADPH oxidase in vascular proliferative diseasesThe IFN-gamma-induced transcriptional program of the CIITA gene is inhibited by statins.Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB-dependent pathway.Ras and RhoA suppress whereas RhoB enhances cytokine-induced transcription of nitric oxide synthase-2 in human normal liver AKN-1 cells and lung cancer A-549 cells.IFN-gamma + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38(mapk) in a mouse macrophage cell line.The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors. A potential mechanism for GGTI-298 antitumor activity.Epac2-Rap1 Signaling Regulates Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias.The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner.Inhibition of small G proteins of the rho family by statins or clostridium difficile toxin B enhances cytokine-mediated induction of NO synthase II.Selected contribution: insulin utilizes NO/cGMP pathway to activate myosin phosphatase via Rho inhibition in vascular smooth muscle.Signal transduction pathways of IL-1beta-mediated iNOS in pulmonary vascular smooth muscle cells.Statins and modulation of oxidative stress.Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins.Statin enhances cytokine-mediated induction of nitric oxide synthesis in vascular smooth muscle cells.Small interfering RNA against ERK1/2 attenuates cigarette smoke-induced pulmonary vascular remodeling.Anticancer activity of farnesyltransferase and geranylgeranyltransferase I inhibitors: prospects for drug development.
P2860
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P2860
Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells
description
1997 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1997
@ast
im Mai 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/05/23)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/05/23)
@nl
наукова стаття, опублікована в травні 1997
@uk
name
Inhibition of protein geranylg ...... n vascular smooth muscle cells
@ast
Inhibition of protein geranylg ...... n vascular smooth muscle cells
@en
Inhibition of protein geranylg ...... n vascular smooth muscle cells
@nl
type
label
Inhibition of protein geranylg ...... n vascular smooth muscle cells
@ast
Inhibition of protein geranylg ...... n vascular smooth muscle cells
@en
Inhibition of protein geranylg ...... n vascular smooth muscle cells
@nl
prefLabel
Inhibition of protein geranylg ...... n vascular smooth muscle cells
@ast
Inhibition of protein geranylg ...... n vascular smooth muscle cells
@en
Inhibition of protein geranylg ...... n vascular smooth muscle cells
@nl
P2093
P2860
P356
P1476
Inhibition of protein geranylg ...... n vascular smooth muscle cells
@en
P2093
A. D. Hamilton
J. D. Finder
J. L. Litz
M. A. Blaskovich
S. M. Sebti
T. F. McGuire
P2860
P304
13484–13488
P356
10.1074/JBC.272.21.13484
P407
P577
1997-05-23T00:00:00Z