The evolutionary pressure to inactivate. A subclass of synaptotagmins with an amino acid substitution that abolishes Ca2+ binding
about
Synaptotagmin gene content of the sequenced genomesFunctional and biochemical analysis of the C2 domains of synaptotagmin IVSynaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cellsSynaptotagmin-1 and synaptotagmin-7 trigger synchronous and asynchronous phases of neurotransmitter releaseCalcium control of neurotransmitter releaseDifferential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter releaseAn unusual C(2)-domain in the active-zone protein piccolo: implications for Ca(2+) regulation of neurotransmitter release.The functional significance of synaptotagmin diversity in neuroendocrine secretionSynaptotagmin IV acts as a multi-functional regulator of Ca2+-dependent exocytosisUpregulation of synaptotagmin IV inhibits transmitter release in PC12 cells with targeted synaptotagmin I knockdownSynaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic β-cellsThe human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificityBinding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion moleculesSynaptotagmin IV regulates glial glutamate releaseInjured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis.Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reactionSynaptotagmin IV is present at the Golgi and distal parts of neuritesSynthesis degradation, and subcellular localization of synaptotagmin IV, a neuronal immediate early gene productStructural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagminSynaptotagmin VII regulates Ca(2+)-dependent exocytosis of lysosomes in fibroblastsRat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusionSynaptotagmin-11 inhibits clathrin-mediated and bulk endocytosisThe AP2 binding site of synaptotagmin 1 is not an internalization signal but a regulator of endocytosisSynaptotagmin IV modulation of vesicle size and fusion pores in PC12 cellsJNK phosphorylates synaptotagmin-4 and enhances Ca2+-evoked releaseA novel alternatively spliced variant of synaptotagmin VI lacking a transmembrane domain. Implications for distinct functions of the two isoformsSynaptotagmin IV: a multifunctional regulator of peptidergic nerve terminalsConserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and XSinging, but not seizure, induces synaptotagmin IV in zebra finch song circuit nuclei.C2-domains, structure and function of a universal Ca2+-binding domainA manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes--an open access resource for neuroscience and evolutionary biology.Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells.Mass spectrometry screening reveals peptides modulated differentially in the medial prefrontal cortex of rats with disparate initial sensitivity to cocaine.Phylogenetic analysis of ferlin genes reveals ancient eukaryotic origins.Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addictionSynaptotagmin I is a molecular target for lead.C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I.Slp4-a/granuphilin-a regulates dense-core vesicle exocytosis in PC12 cells.Synapsins I and II are ATP-binding proteins with differential Ca2+ regulation.
P2860
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P2860
The evolutionary pressure to inactivate. A subclass of synaptotagmins with an amino acid substitution that abolishes Ca2+ binding
description
1997 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1997
@ast
im Mai 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/05/30)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/05/30)
@nl
наукова стаття, опублікована в травні 1997
@uk
name
The evolutionary pressure to i ...... on that abolishes Ca2+ binding
@ast
The evolutionary pressure to i ...... on that abolishes Ca2+ binding
@en
The evolutionary pressure to i ...... on that abolishes Ca2+ binding
@nl
type
label
The evolutionary pressure to i ...... on that abolishes Ca2+ binding
@ast
The evolutionary pressure to i ...... on that abolishes Ca2+ binding
@en
The evolutionary pressure to i ...... on that abolishes Ca2+ binding
@nl
prefLabel
The evolutionary pressure to i ...... on that abolishes Ca2+ binding
@ast
The evolutionary pressure to i ...... on that abolishes Ca2+ binding
@en
The evolutionary pressure to i ...... on that abolishes Ca2+ binding
@nl
P2093
P2860
P3181
P356
P1476
The evolutionary pressure to i ...... on that abolishes Ca2+ binding
@en
P2093
C. von Poser
K. Ichtchenko
P2860
P304
14314–14319
P3181
P356
10.1074/JBC.272.22.14314
P407
P577
1997-05-30T00:00:00Z