Ref-1/Ape is critical for formation of the hypoxia-inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene
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Dynamic Regulation of APE1/Ref-1 as a Therapeutic Target ProteinNucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cellsMechanism of hypoxia-inducible factor 1 alpha-mediated Mcl1 regulation in Helicobacter pylori-infected human gastric epithelium.Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein.The many functions of APE1/Ref-1: not only a DNA repair enzymeRegulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response.Redox regulation of DNA repair: implications for human health and cancer therapeutic development.Apurinic/apyrimidinic endonuclease/redox effector factor-1(APE/Ref-1): a unique target for the prevention and treatment of human melanoma.Gastric microbiome and gastric cancerControlled DNA "damage" and repair in hypoxic signalingDual inhibition of plasminogen kringle 5 on angiogenesis and chemotaxis suppresses tumor metastasis by targeting HIF-1α pathway.Killing effect of Ad5/F35-APE1 siRNA recombinant adenovirus in combination with hematoporphrphyrin derivative-mediated photodynamic therapy on human nonsmall cell lung cancerA novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta.Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and functionHypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis.Abnormal histone methylation is responsible for increased vascular endothelial growth factor 165a secretion from airway smooth muscle cells in asthma.Accumulation of oxidatively generated DNA damage in the brain: a mechanism of neurotoxicity.An oxidative DNA "damage" and repair mechanism localized in the VEGF promoter is important for hypoxia-induced VEGF mRNA expression.Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damageHuman apurinic/apyrimidinic endonuclease siRNA inhibits the angiogenesis induced by X-ray irradiation in lung cancer cells.The transcription factor GATA1 and the histone methyltransferase SET7 interact to promote VEGF-mediated angiogenesis and tumor growth and predict clinical outcome of breast cancerInhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited.Ape1/Ref-1 induces glial cell-derived neurotropic factor (GDNF) responsiveness by upregulating GDNF receptor alpha1 expressionOxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice.Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells.Differential regulation of human PlGF gene expression in trophoblast and nontrophoblast cells by oxygen tension.Apurinic/apyrimidinic endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal cancer tissuesTranscriptional regulation by hypoxia inducible factors.Perinuclear mitochondrial clustering creates an oxidant-rich nuclear domain required for hypoxia-induced transcriptionTreatment of synchronous adenocarcinoma and lymphoma of the stomach: A case reportProtein-disulfide isomerase regulates the thyroid hormone receptor-mediated gene expression via redox factor-1 through thiol reduction-oxidation.Hypoxia induced gene expression: the specificity switch!DNA damage mediates changes in neuronal sensitivity induced by the inflammatory mediators, MCP-1 and LPS, and can be reversed by enhancing the DNA repair function of APE1.Gene expression profile of B 16(F10) murine melanoma cells exposed to hypoxic conditions in vitro.
P2860
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P2860
Ref-1/Ape is critical for formation of the hypoxia-inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene
description
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im Juni 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/06/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/06/01)
@nl
наукова стаття, опублікована в червні 2004
@uk
مقالة علمية (نشرت في يونيو 2004)
@ar
name
Ref-1/Ape is critical for form ...... ery endothelial cell VEGF gene
@ast
Ref-1/Ape is critical for form ...... ery endothelial cell VEGF gene
@en
Ref-1/Ape is critical for form ...... ery endothelial cell VEGF gene
@nl
type
label
Ref-1/Ape is critical for form ...... ery endothelial cell VEGF gene
@ast
Ref-1/Ape is critical for form ...... ery endothelial cell VEGF gene
@en
Ref-1/Ape is critical for form ...... ery endothelial cell VEGF gene
@nl
prefLabel
Ref-1/Ape is critical for form ...... ery endothelial cell VEGF gene
@ast
Ref-1/Ape is critical for form ...... ery endothelial cell VEGF gene
@en
Ref-1/Ape is critical for form ...... ery endothelial cell VEGF gene
@nl
P2093
P921
P3181
P356
P1433
P1476
Ref-1/Ape is critical for form ...... ery endothelial cell VEGF gene
@en
P2093
Clayton C. Campbell
Glenn L. Wilson
Kathryn A. Ziel
Mark N. Gillespie
P304
P3181
P356
10.1096/FJ.03-1160FJE
P407
P577
2004-06-01T00:00:00Z