Caveolae modulate excitation-contraction coupling and beta2-adrenergic signalling in adult rat ventricular myocytes
about
Stimulation of ICa by basal PKA activity is facilitated by caveolin-3 in cardiac ventricular myocytesCaV1.2 signaling complexes in the heartL-type calcium channel targeting and local signalling in cardiac myocytesRegulation of the cardiac sodium pumpPopeye domain containing 1 (Popdc1/Bves) is a caveolae-associated protein involved in ischemia toleranceCaveolae, ion channels and cardiac arrhythmias.Caveolae create local signalling domains through their distinct protein content, lipid profile and morphologyCaveolin contributes to the modulation of basal and β-adrenoceptor stimulated function of the adult rat ventricular myocyte by simvastatin: a novel pleiotropic effectSarcolemmal cholesterol and caveolin-3 dependence of cardiac function, ischemic tolerance, and opioidergic cardioprotectionAgonist-induced localization of Gq-coupled receptors and G protein-gated inwardly rectifying K+ (GIRK) channels to caveolae determines receptor specificity of phosphatidylinositol 4,5-bisphosphate signaling.Effects of cholesterol depletion on compartmentalized cAMP responses in adult cardiac myocytes.Couplons in rat atria form distinct subgroups defined by their molecular partners.Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling.Alterations of excitation-contraction coupling and excitation coupled Ca(2+) entry in human myotubes carrying CAV3 mutations linked to rippling muscleG-protein alpha-s and -12 subunits are involved in androgen-stimulated PI3K activation and androgen receptor transactivation in prostate cancer cells.Identification of caveolar resident proteins in ventricular myocytes using a quantitative proteomic approach: dynamic changes in caveolar composition following adrenoceptor activation.Different subcellular populations of L-type Ca2+ channels exhibit unique regulation and functional roles in cardiomyocytesRippling muscle disease and facioscapulohumeral dystrophy-like phenotype in a patient carrying a heterozygous CAV3 T78M mutation and a D4Z4 partial deletion: Further evidence for "double trouble" overlapping syndromesInteraction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor.Aging, metabolic syndrome and the heart.A specific pattern of phosphodiesterases controls the cAMP signals generated by different Gs-coupled receptors in adult rat ventricular myocytes.Biased β2-adrenoceptor signalling in heart failure: pathophysiology and drug discovery.Direct Evidence for Microdomain-Specific Localization and Remodeling of Functional L-Type Calcium Channels in Rat and Human Atrial Myocytes.Spatial control of the βAR system in heart failure: the transverse tubule and beyond.Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load.Cholesterol Depletion Alters Cardiomyocyte Subcellular Signaling and Increases Contractility.Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-adrenergic stimulation.Lipid microdomains and the regulation of ion channel function.Distinct physiological effects of β1- and β2-adrenoceptors in mouse ventricular myocytes: insights from a compartmentalized mathematical model.Cholesterol is required for maintaining T-tubule integrity and intercellular connections at intercalated discs in cardiomyocytesCaveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyteNovel synthetic sulfoglycolipid IG20 facilitates exocytosis in chromaffin cells through the regulation of sodium channels.Functional subcellular distribution of β1- and β2-adrenergic receptors in rat ventricular cardiac myocytes.Caveolae in Rabbit Ventricular Myocytes: Distribution and Dynamic Diminution after Cell Isolation.Caveolin-3 T78M and T78K missense mutations lead to different phenotypes in vivo and in vitro.Cholesterol depletion does not alter the capacitance or Ca handling of the surface or t-tubule membranes in mouse ventricular myocytes.Loss of caveolin-3-dependent regulation of ICa in rat ventricular myocytes in heart failure.Cavin-1 deficiency modifies myocardial and coronary function, stretch responses and ischaemic tolerance: roles of NOS over-activity.The structure and function of cardiac t-tubules in health and disease.The Development of Compartmentation of cAMP Signaling in Cardiomyocytes: The Role of T-Tubules and Caveolae Microdomains.
P2860
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P2860
Caveolae modulate excitation-contraction coupling and beta2-adrenergic signalling in adult rat ventricular myocytes
description
2006 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im März 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/03/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/03/01)
@nl
наукова стаття, опублікована в березні 2006
@uk
مقالة علمية (نشرت في مارس 2006)
@ar
name
Caveolae modulate excitation-c ...... adult rat ventricular myocytes
@ast
Caveolae modulate excitation-c ...... adult rat ventricular myocytes
@en
Caveolae modulate excitation-c ...... adult rat ventricular myocytes
@nl
type
label
Caveolae modulate excitation-c ...... adult rat ventricular myocytes
@ast
Caveolae modulate excitation-c ...... adult rat ventricular myocytes
@en
Caveolae modulate excitation-c ...... adult rat ventricular myocytes
@nl
prefLabel
Caveolae modulate excitation-c ...... adult rat ventricular myocytes
@ast
Caveolae modulate excitation-c ...... adult rat ventricular myocytes
@en
Caveolae modulate excitation-c ...... adult rat ventricular myocytes
@nl
P3181
P1476
Caveolae modulate excitation-c ...... adult rat ventricular myocytes
@en
P2093
P304
P3181
P356
10.1016/J.CARDIORES.2005.10.006
P577
2005-11-28T00:00:00Z