Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-adrenergic stimulation. - Wikidata - awgldk - TriplyDB

Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-adrenergic stimulation.

Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-adrenergic stimulation.

http://www.wikidata.org/entity/Q37294805

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Calsequestrin 2 and arrhythmias Catecholaminergic polymorphic ventricular tachycardia: An exciting new era Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells G-protein Coupled Receptor Signaling in Pluripotent Stem Cell-derived Cardiovascular Cells: Implications for Disease Modeling Induced pluripotent stem cells for cardiovascular disease: from product-focused disease modeling to process-focused disease discovery Cardiovascular Disease Modeling Using Patient-Specific Induced Pluripotent Stem Cells Induced pluripotent stem cell-derived cardiomyocytes for cardiovascular disease modeling and drug screening Induced pluripotent stem cell-derived cardiomyocytes in studies of inherited arrhythmias Modelling human disease with pluripotent stem cells iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery Calcium signalling of human pluripotent stem cell-derived cardiomyocytes Clinical Potentials of Cardiomyocytes Derived from Patient-Specific Induced Pluripotent Stem Cells Generation and characterization of functional cardiomyocytes derived from human T cell-derived induced pluripotent stem cells Patient Specific Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Development and Screening In Catecholaminergic Polymorphic Ventricular Tachycardia Translation of Human-Induced Pluripotent Stem Cells: From Clinical Trial in a Dish to Precision Medicine Inherited heart disease - what can we expect from the second decade of human iPS cell research?Human induced pluripotent stem cell-derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes hiPSC Modeling of Inherited Cardiomyopathies Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models Hyperthermia Influences the Effects of Sodium Channel Blocking Drugs in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy.CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia.Modeling Catecholaminergic Polymorphic Ventricular Tachycardia using Induced Pluripotent Stem Cell-derived Cardiomyocytes.Functional abnormalities in iPSC-derived cardiomyocytes generated from CPVT1 and CPVT2 patients carrying ryanodine or calsequestrin mutations RyR2R420Q catecholaminergic polymorphic ventricular tachycardia mutation induces bradycardia by disturbing the coupled clock pacemaker mechanism.Induced Pluripotent Stem Cell-Derived Cardiomyocytes Provide In Vivo Biological Pacemaker Function Modeling Inherited Arrhythmia Disorders Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes.The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications.Cardiac ablation of Rheb1 reduces sodium currents in infant mice Investigating human disease using stem cell models.iPCS Cell Modeling of Inherited Cardiac Arrhythmias.From beat rate variability in induced pluripotent stem cell-derived pacemaker cells to heart rate variability in human subjects.Complete restoration of multiple dystrophin isoforms in genetically corrected Duchenne muscular dystrophy patient-derived cardiomyocytes.Prospects for In Vitro Myofilament Maturation in Stem Cell-Derived Cardiac Myocytes.Novel Analysis Software for Detecting and Classifying Ca2+ Transient Abnormalities in Stem Cell-Derived Cardiomyocytes.Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell-derived cardiac myocyte monolayers.Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias.Engineered heart tissues and induced pluripotent stem cells: Macro- and microstructures for disease modeling, drug screening, and translational studies.

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Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-adrenergic stimulation.

http://www.wikidata.org/entity/Q37294805

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bilimsel makale

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scientific article published on March 2012

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vedecký článok

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Cardiomyocytes generated from ...... e to β-adrenergic stimulation.

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Cardiomyocytes generated from ...... e to β-adrenergic stimulation.

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Cardiomyocytes generated from ...... e to β-adrenergic stimulation.

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Cardiomyocytes generated from ...... e to β-adrenergic stimulation.

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Cardiomyocytes generated from ...... e to β-adrenergic stimulation.

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Cardiomyocytes generated from ...... e to β-adrenergic stimulation.

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J.1582-4934.2011.01476.X

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Journal of Cellular and Molecular Medicine

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Cardiomyocytes generated from ...... e to β-adrenergic stimulation.

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Atara Novak

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Avraham Lorber

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Joseph Itskovitz-Eldor

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Lili Barad

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Naama Zeevi-Levin

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Ofer Binah

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Revital Shick

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Ronit Shtrichman

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P2860

Clinical phenotype and functional characterization of CASQ2 mutations associated with catecholaminergic polymorphic ventricular tachycardia

Abnormal interactions of calsequestrin with the ryanodine receptor calcium release channel complex linked to exercise-induced sudden cardiac death

Induced pluripotent stem cell lines derived from human somatic cells

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia

A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel

Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia

Abnormal calcium signaling and sudden cardiac death associated with mutation of calsequestrin

Caveolae modulate excitation-contraction coupling and beta2-adrenergic signalling in adult rat ventricular myocytes

The calsequestrin mutation CASQ2D307H does not affect protein stability and targeting to the junctional sarcoplasmic reticulum but compromises its dynamic regulation of calcium buffering

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10.1111/J.1582-4934.2011.01476.X

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Naama Zeevi-Levin

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2012-03-01T00:00:00Z

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51767942

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