Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor
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Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7G protein-coupled receptor kinase 2 and arrestin2 regulate arterial smooth muscle P2Y-purinoceptor signallingArresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4A simple method for quantifying functional selectivity and agonist biasBihelix: Towards de novo structure prediction of an ensemble of G-protein coupled receptor conformations.CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathway.Src is required for mechanical stretch-induced cardiomyocyte hypertrophy through angiotensin II type 1 receptor-dependent β-arrestin2 pathways.GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Gα(q/11) and β-arrestin-dependent manner.Ligand-directed signalling at beta-adrenoceptorsSeven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Beyond desensitization: physiological relevance of arrestin-dependent signaling.GPR54 (KISS1R) transactivates EGFR to promote breast cancer cell invasiveness.Teaching old receptors new tricks: biasing seven-transmembrane receptors.Arrestin-dependent angiotensin AT1 receptor signaling regulates Akt and mTor-mediated protein synthesis.Functional selectivity in adrenergic and angiotensin signaling systems.Early endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomesΒ-arrestin: a signaling molecule and potential therapeutic target for heart failure.β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration.ERK5 activation by Gq-coupled muscarinic receptors is independent of receptor internalization and β-arrestin recruitmentArrestin development: emerging roles for beta-arrestins in developmental signaling pathwaysGRK2 and β-arrestins in cardiovascular disease: Something old, something new.Alpha1a-Adrenoceptor Genetic Variant Triggers Vascular Smooth Muscle Cell Hyperproliferation and Agonist Induced Hypertrophy via EGFR Transactivation Pathway.Arrestins 2 and 3 differentially regulate ETA and P2Y2 receptor-mediated cell signaling and migration in arterial smooth muscle.The GTPase ARF6 Controls ROS Production to Mediate Angiotensin II-Induced Vascular Smooth Muscle Cell ProliferationDefining the roles of arrestin2 and arrestin3 in vasoconstrictor receptor desensitization in hypertension.Activated human hydroxy-carboxylic acid receptor-3 signals to MAP kinase cascades via the PLC-dependent PKC and MMP-mediated EGFR pathways.International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected].Effects of small platform catheter-based left ventricular assist device support on regional myocardial signal transduction.β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury.The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome.Non-Hematopoietic β-Arrestin1 Confers Protection Against Experimental Colitis.Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases.Therapeutic potential of β-arrestin- and G protein-biased agonists.Endosomes: a legitimate platform for the signaling train.β-Arrestin mediates the Frank-Starling mechanism of cardiac contractilityMinireview: More than just a hammer: ligand "bias" and pharmaceutical discovery.Functional relevance of biased signaling at the angiotensin II type 1 receptor.G protein-dependent and G protein-independent signaling pathways and their impact on cardiac function.Cellular functions regulated by phosphorylation of EGFR on Tyr845.Non-canonical signalling and roles of the vasoactive peptides angiotensins and kinins.
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Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor
description
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2009
@ast
im Mai 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/05/01)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/05/01)
@nl
наукова стаття, опублікована в травні 2009
@uk
name
Independent beta-arrestin2 and ...... idermal growth factor receptor
@ast
Independent beta-arrestin2 and ...... idermal growth factor receptor
@en
Independent beta-arrestin2 and ...... idermal growth factor receptor
@nl
type
label
Independent beta-arrestin2 and ...... idermal growth factor receptor
@ast
Independent beta-arrestin2 and ...... idermal growth factor receptor
@en
Independent beta-arrestin2 and ...... idermal growth factor receptor
@nl
prefLabel
Independent beta-arrestin2 and ...... idermal growth factor receptor
@ast
Independent beta-arrestin2 and ...... idermal growth factor receptor
@en
Independent beta-arrestin2 and ...... idermal growth factor receptor
@nl
P2093
P2860
P356
P1476
Independent beta-arrestin2 and ...... idermal growth factor receptor
@en
P2093
Keshava Rajagopal
Robert J. Lefkowitz
Seungkirl Ahn
P2860
P304
11953–11962
P356
10.1074/JBC.M808176200
P407
P577
2009-05-01T00:00:00Z