Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction
about
Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependenceSmall molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice.The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer's Disease NeuropathologyDifferences in abundances of cell-signalling proteins in blood reveal novel biomarkers for early detection of clinical Alzheimer's diseaseResilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal Alzheimer's disease.Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomainProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neuronsCholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice.APP regulates NGF receptor trafficking and NGF-mediated neuronal differentiation and survival.Soluble β-amyloid Precursor Protein Alpha binds to p75 neurotrophin receptor to promote neurite outgrowth.The effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by γ-secretaseBRET Biosensor Analysis of Receptor Tyrosine Kinase Functionality.RAGE is a key cellular target for Abeta-induced perturbation in Alzheimer's disease.Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents.Basic mechanisms of neurodegeneration: a critical update.Structural and functional alterations in amyloid-β precursor protein induced by amyloid-β peptides.Importance of the caspase cleavage site in amyloid-β protein precursorConvergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development.Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging.Chopper is prodeath regardless of the effect of p75ICD on sensitivity to oxidative stress.One protein, multiple pathologies: multifaceted involvement of amyloid β in neurodegenerative disorders of the brain and retina.Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for Alzheimer's Disease.Paradoxical effect of TrkA inhibition in Alzheimer's disease models.Complexity and Selectivity of γ-Secretase Cleavage on Multiple Substrates: Consequences in Alzheimer's Disease and Cancer.p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis.
P2860
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P2860
Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction
description
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im März 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/03/01)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/03/01)
@nl
наукова стаття, опублікована в березні 2009
@uk
مقالة علمية (نشرت في مارس 2009)
@ar
name
Selective vulnerability in Alz ...... otein and p75(NTR) interaction
@ast
Selective vulnerability in Alz ...... otein and p75(NTR) interaction
@en
Selective vulnerability in Alz ...... otein and p75(NTR) interaction
@nl
type
label
Selective vulnerability in Alz ...... otein and p75(NTR) interaction
@ast
Selective vulnerability in Alz ...... otein and p75(NTR) interaction
@en
Selective vulnerability in Alz ...... otein and p75(NTR) interaction
@nl
prefLabel
Selective vulnerability in Alz ...... otein and p75(NTR) interaction
@ast
Selective vulnerability in Alz ...... otein and p75(NTR) interaction
@en
Selective vulnerability in Alz ...... otein and p75(NTR) interaction
@nl
P2093
P2860
P356
P1433
P1476
Selective vulnerability in Alz ...... otein and p75(NTR) interaction
@en
P2093
Dale E. Bredesen
Joanna Fombonne
Patrick Mehlen
Shahrooz Rabizadeh
Surita Banwait
P2860
P304
P356
10.1002/ANA.21578
P577
2009-03-01T00:00:00Z