Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. - Wikidata - awgldk - TriplyDB

Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.

Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.

http://www.wikidata.org/entity/Q34598626

about

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer's disease Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosis The amyloid precursor protein: beyond amyloid Amyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's disease The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6 Zinc-mediated Allosteric Inhibition of Caspase-6 Phosphorylation regulates assembly of the caspase-6 substrate-binding groove.APP processing in Alzheimer's disease Proteolytic processing of Alzheimer's β-amyloid precursor protein Cell death in the nervous system Transgenic expression of the amyloid-beta precursor protein-intracellular domain does not induce Alzheimer's Disease-like traits in vivo Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production.APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD).Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease.Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides.Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network.Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease.Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila Cardiomyocyte contractile dysfunction in the APPswe/PS1dE9 mouse model of Alzheimer's disease Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain.Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway.Structural and functional characterization of a novel FE65 protein product up-regulated in cognitively impaired FE65 knockout mice.C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins.Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo.Caspase cleavage of the amyloid precursor protein is prevented after overexpression of bcl-2 in a triple transgenic mouse model of Alzheimer's disease Late-onset Alzheimer's disease, heating up and foxed by several proteins: pathomolecular effects of the aging process.Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomain Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models Reversal of cognitive decline: a novel therapeutic program Neuroinflammation and neuronal loss precede Aβ plaque deposition in the hAPP-J20 mouse model of Alzheimer's disease.Hot topics in aging research: protein translation and TOR signaling, 2010

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Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.

http://www.wikidata.org/entity/Q34598626

description

2006 nî lūn-bûn

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2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2006 թվականի ապրիլին հրատարակված գիտական հոդված

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2006年の論文

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年學術文章

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Reversal of Alzheimer's-like p ...... ic mice by mutation of Asp664.

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Reversal of Alzheimer's-like p ...... ic mice by mutation of Asp664.

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Reversal of Alzheimer's-like p ...... ic mice by mutation of Asp664.

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Reversal of Alzheimer's-like p ...... ic mice by mutation of Asp664.

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Reversal of Alzheimer's-like p ...... ic mice by mutation of Asp664.

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Reversal of Alzheimer's-like p ...... ic mice by mutation of Asp664.

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Reversal of Alzheimer's-like p ...... ic mice by mutation of Asp664.

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Reversal of Alzheimer's-like p ...... ic mice by mutation of Asp664.

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Reversal of Alzheimer's-like p ...... ic mice by mutation of Asp664.

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Proceedings of the National Academy of Sciences of the United States of America

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Reversal of Alzheimer's-like p ...... ic mice by mutation of Asp664.

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Anna V Logvinova

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Dale E Bredesen

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David A Greenberg

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Elaine Carlson

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Kunlin Jin

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Marina Ataie

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Nathalie Chevallier

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Olivia F Gorostiza

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Sandhya Sitaraman

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Sarah A Sagi

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P2860

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment

Alzheimer's disease is a synaptic failure

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

Developments of a water-maze procedure for studying spatial learning in the rat

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein

Increased hippocampal neurogenesis in Alzheimer's disease.

Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis.

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