Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.
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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's diseaseNeurodegeneration in Alzheimer's disease: caspases and synaptic element interdependenceIncreased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer's diseaseDysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosisThe amyloid precursor protein: beyond amyloidAmyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's diseaseThe multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foesSubstrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6Zinc-mediated Allosteric Inhibition of Caspase-6Phosphorylation regulates assembly of the caspase-6 substrate-binding groove.APP processing in Alzheimer's diseaseProteolytic processing of Alzheimer's β-amyloid precursor proteinCell death in the nervous systemTransgenic expression of the amyloid-beta precursor protein-intracellular domain does not induce Alzheimer's Disease-like traits in vivoSelective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interactionThe autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production.APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD).Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease.Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides.Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network.Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor proteinAPP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutantRescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease.Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in DrosophilaCardiomyocyte contractile dysfunction in the APPswe/PS1dE9 mouse model of Alzheimer's diseaseAbnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain.Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway.Structural and functional characterization of a novel FE65 protein product up-regulated in cognitively impaired FE65 knockout mice.C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's diseaseInhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins.Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo.Caspase cleavage of the amyloid precursor protein is prevented after overexpression of bcl-2 in a triple transgenic mouse model of Alzheimer's diseaseLate-onset Alzheimer's disease, heating up and foxed by several proteins: pathomolecular effects of the aging process.Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomainUsing mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse modelsReversal of cognitive decline: a novel therapeutic programNeuroinflammation and neuronal loss precede Aβ plaque deposition in the hAPP-J20 mouse model of Alzheimer's disease.Hot topics in aging research: protein translation and TOR signaling, 2010
P2860
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P2860
Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
name
Reversal of Alzheimer's-like p ...... ic mice by mutation of Asp664.
@ast
Reversal of Alzheimer's-like p ...... ic mice by mutation of Asp664.
@en
Reversal of Alzheimer's-like p ...... ic mice by mutation of Asp664.
@nl
type
label
Reversal of Alzheimer's-like p ...... ic mice by mutation of Asp664.
@ast
Reversal of Alzheimer's-like p ...... ic mice by mutation of Asp664.
@en
Reversal of Alzheimer's-like p ...... ic mice by mutation of Asp664.
@nl
prefLabel
Reversal of Alzheimer's-like p ...... ic mice by mutation of Asp664.
@ast
Reversal of Alzheimer's-like p ...... ic mice by mutation of Asp664.
@en
Reversal of Alzheimer's-like p ...... ic mice by mutation of Asp664.
@nl
P2093
P2860
P356
P1476
Reversal of Alzheimer's-like p ...... ic mice by mutation of Asp664.
@en
P2093
Anna V Logvinova
Dale E Bredesen
David A Greenberg
Elaine Carlson
Kunlin Jin
Marina Ataie
Nathalie Chevallier
Olivia F Gorostiza
Sandhya Sitaraman
Sarah A Sagi
P2860
P304
P356
10.1073/PNAS.0509695103
P407
P577
2006-04-25T00:00:00Z