Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A
about
E-type prostanoid receptor 4 (EP4) in disease and therapyThe cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity.Arterial graft with elastic layer structure grown from cellsFailure of postnatal ductus arteriosus closure in prostaglandin transporter-deficient mice.The future of EPAC-targeted therapies: agonism versus antagonismHydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signallingCyclic nucleotide signalling in kidney fibrosis.Current Perspectives on Pathobiology of the Ductus Arteriosus.Airway Epithelial Cell Release of GABA is Regulated by Protein Kinase A.Inhibition of Epac1 suppresses mitochondrial fission and reduces neointima formation induced by vascular injury.T-type Ca2+ channels promote oxygenation-induced closure of the rat ductus arteriosus not only by vasoconstriction but also by neointima formation.The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function.Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system.Attenuation of ductus arteriosus intimal thickening in preterm sheep twins compared with singletons.EPAC activation inhibits acetaldehyde-induced activation and proliferation of hepatic stellate cell via Rap1.Pathology and molecular mechanisms of coarctation of the aorta and its association with the ductus arteriosus.Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades.Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.Tissue-type plasminogen activator contributes to remodeling of the rat ductus arteriosus.Extracellular polysaccharides purified from Aureobasidium pullulans SM‑2001 (Polycan) inhibit dexamethasone‑induced muscle atrophy in mice.Epac activation inhibits IL-6-induced cardiac myocyte dysfunction.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.Isolation and culture of fibroblasts, vascular smooth muscle, and endothelial cells from the fetal rat ductus arteriosus.
P2860
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P2860
Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A
description
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2008
@ast
im Oktober 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/10/17)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/10/17)
@nl
наукова стаття, опублікована в жовтні 2008
@uk
name
Prostaglandin E2-activated Epa ...... AMP-dependent protein kinase A
@ast
Prostaglandin E2-activated Epa ...... AMP-dependent protein kinase A
@en
Prostaglandin E2-activated Epa ...... AMP-dependent protein kinase A
@nl
type
label
Prostaglandin E2-activated Epa ...... AMP-dependent protein kinase A
@ast
Prostaglandin E2-activated Epa ...... AMP-dependent protein kinase A
@en
Prostaglandin E2-activated Epa ...... AMP-dependent protein kinase A
@nl
prefLabel
Prostaglandin E2-activated Epa ...... AMP-dependent protein kinase A
@ast
Prostaglandin E2-activated Epa ...... AMP-dependent protein kinase A
@en
Prostaglandin E2-activated Epa ...... AMP-dependent protein kinase A
@nl
P2093
P2860
P3181
P356
P1476
Prostaglandin E2-activated Epa ...... AMP-dependent protein kinase A
@en
P2093
Mayumi Watanabe
Meihua Jin
Motohiko Sato
Qibin Jiao
Sayaka Suzuki
Shigeru Nishimaki
Shiho Iwasaki
Susumu Minamisawa
P2860
P304
28702–28709
P3181
P356
10.1074/JBC.M804223200
P407
P577
2008-10-17T00:00:00Z