Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy.
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Role of EPAC in cAMP-Mediated Actions in Adrenocortical CellsEpac enhances excitation-transcription coupling in cardiac myocytesEpac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migrationProstaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase ADifferential distribution of exchange proteins directly activated by cyclic AMP within the adult rat retinaEpac2 induces synapse remodeling and depression and its disease-associated forms alter spinesExchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeuticsRecent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).Epac is required for GLP-1R-mediated inhibition of oxidative stress and apoptosis in cardiomyocytesDifferential roles of Epac in regulating cell death in neuronal and myocardial cells.Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitorsBlocking of exchange proteins directly activated by cAMP leads to reduced replication of Middle East respiratory syndrome coronavirus.Epac and PKA: a tale of two intracellular cAMP receptors.A kinase anchor protein 150 (AKAP150)-associated protein kinase A limits dendritic spine density.Epac1-mediated, high glucose-induced renal proximal tubular cells hypertrophy via the Akt/p21 pathwayNovel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes.cAMP signalling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of EpaccAMP-mediated secretion of brain-derived neurotrophic factor in developing airway smooth muscle.Social, communication, and cortical structural impairments in Epac2-deficient mice.Functionalized N,N-Diphenylamines as Potent and Selective EPAC2 Inhibitors.Sex Steroids Influence Brain-Derived Neurotropic Factor Secretion From Human Airway Smooth Muscle Cells.The cAMP binding protein Epac regulates cardiac myofilament function.Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect.Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1.EPAC proteins transduce diverse cellular actions of cAMP.Epac increases melanoma cell migration by a heparan sulfate-related mechanism.Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling.The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function.Role of Epac in brain and heart.Epac proteins: specific ligands and role in cardiac remodelling.Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets.The role of Epac in the heart.Epac2-Rap1 Signaling Regulates Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias.Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity.NFATc3-dependent loss of I(to) gradient across the left ventricular wall during chronic beta adrenergic stimulation.Growth hormone-releasing hormone attenuates cardiac hypertrophy and improves heart function in pressure overload-induced heart failure.Early effects of Epac depend on the fine-tuning of the sarcoplasmic reticulum Ca2+ handling in cardiomyocytes.Molecular pathways of oestrogen receptors and β-adrenergic receptors in cardiac cells: Recognition of their similarities, interactions and therapeutic value.Epac Function and cAMP Scaffolds in the Heart and Lung.
P2860
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P2860
Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Developmental changes in gene ...... ion in myocardial hypertrophy.
@en
type
label
Developmental changes in gene ...... ion in myocardial hypertrophy.
@en
prefLabel
Developmental changes in gene ...... ion in myocardial hypertrophy.
@en
P2093
P1476
Developmental changes in gene ...... tion in myocardial hypertrophy
@en
P2093
Coskun Ulucan
Erdene Baljinnyam
Motohiko Sato
Satoshi Okumura
Shinichi Hirotani
Yoshihiro Ishikawa
Yunzhe Bai
P304
P356
10.1152/AJPHEART.00159.2007
P577
2007-06-08T00:00:00Z