Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis
about
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation.Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetesLean heart: Role of leptin in cardiac hypertrophy and metabolismAMPK: a cellular metabolic and redox sensor. A minireviewAlterations in mouse hypothalamic adipokine gene expression and leptin signaling following chronic spinal cord injury and with advanced ageDiabetic cardiomyopathy: signaling defects and therapeutic approachesTang-Nai-Kang alleviates pre-diabetes and metabolic disorders and induces a gene expression switch toward fatty acid oxidation in SHR.Cg-Leprcp/NDmcr ratsIdentification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factorsHyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice.Leptin protects cardiomyocytes from serum-deprivation-induced apoptosis by increasing anti-oxidant defence.Lipotoxicity in the heart.Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver.Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells.Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action.Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition poreCaloric restriction in leptin deficiency does not correct myocardial steatosis: failure to normalize PPAR{alpha}/PGC1{alpha} and thermogenic glycerolipid/fatty acid cycling.Severity of diabetes governs vascular lipoprotein lipase by affecting enzyme dimerization and disassemblyRoles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasisThe role of intramuscular lipid in insulin resistance.Site and mechanism of leptin action in a rodent form of congenital lipodystrophyCentral leptin signaling is required to normalize myocardial fatty acid oxidation rates in caloric-restricted ob/ob mice.AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity.Obesity-induced changes in kidney mitochondria and endoplasmic reticulum in the presence or absence of leptinThe role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity.Cardiomyocyte-specific deletion of leptin receptors causes lethal heart failure in Cre-recombinase-mediated cardiotoxicity.Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy.Signalling mechanisms underlying the metabolic and other effects of adipokines on the heart.Leptin augments the acute suppressive effects of insulin on hepatic very low-density lipoprotein production in rats.Neuroendocrine and cardiac metabolic dysfunction and NLRP3 inflammasome activation in adipose tissue and pancreas following chronic spinal cord injury in the mouse.Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase.Protein-mediated Fatty Acid Uptake in the Heart.Leptin signaling in the failing and mechanically unloaded human heart.Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors.RNA SEQ Analysis Indicates that the AE3 Cl-/HCO3- Exchanger Contributes to Active Transport-Mediated CO2 Disposal in Heart.Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolism.Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion.Roles of Fatty Acid oversupply and impaired oxidation in lipid accumulation in tissues of obese rats.Hypertrophic cardiomyopathy and dysregulation of cardiac energetics in a mouse model of biliary fibrosisbeta-Agonist stimulation produces changes in cardiac AMPK and coronary lumen LPL only during increased workload.Raspberry ketone, a naturally occurring phenolic compound, inhibits adipogenic and lipogenic gene expression in 3T3-L1 adipocytes.
P2860
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P2860
Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis
description
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2002
@ast
im August 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/08/16)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/08/16)
@nl
наукова стаття, опублікована в серпні 2002
@uk
name
Leptin activates cardiac fatty ...... A carboxylase-malonyl-CoA axis
@ast
Leptin activates cardiac fatty ...... A carboxylase-malonyl-CoA axis
@en
Leptin activates cardiac fatty ...... A carboxylase-malonyl-CoA axis
@nl
type
label
Leptin activates cardiac fatty ...... A carboxylase-malonyl-CoA axis
@ast
Leptin activates cardiac fatty ...... A carboxylase-malonyl-CoA axis
@en
Leptin activates cardiac fatty ...... A carboxylase-malonyl-CoA axis
@nl
prefLabel
Leptin activates cardiac fatty ...... A carboxylase-malonyl-CoA axis
@ast
Leptin activates cardiac fatty ...... A carboxylase-malonyl-CoA axis
@en
Leptin activates cardiac fatty ...... A carboxylase-malonyl-CoA axis
@nl
P2093
P2860
P356
P1476
Leptin activates cardiac fatty ...... A carboxylase-malonyl-CoA axis
@en
P2093
Gary D. Lopaschuk
Laura L. Atkinson
Melanie A. Fischer
P2860
P304
29424–29430
P356
10.1074/JBC.M203813200
P407
P577
2002-08-16T00:00:00Z