Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation
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Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic functionMutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arseniteRegulation of Bim in Health and DiseasePutting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?FoxO3a is activated and executes neuron death via Bim in response to β-amyloidNerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of BimRole and regulation of Cdc25A phosphatase in neuron death induced by NGF deprivation or β-amyloidN-cadherin mediates neuronal cell survival through Bim down-regulation.Bim, Bak, and Bax regulate osteoblast survival.Inhibition by anandamide of 6-hydroxydopamine-induced cell death in PC12 cells.The essential role of p53-up-regulated modulator of apoptosis (Puma) and its regulation by FoxO3a transcription factor in β-amyloid-induced neuron death.G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression.Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes.The MEK-ERK pathway negatively regulates bim expression through the 3' UTR in sympathetic neurons.Contracting the 'mus cells'--does down-sizing suit us for diving into the memory pool?SOD3 decreases ischemic injury derived apoptosis through phosphorylation of Erk1/2, Akt, and FoxO3a.Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus.BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy responseDiva/BclB regulates differentiation by inhibiting NDPKB/Nm23H2-mediated neuronal differentiation in PC-12 cells.Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.Cell cycle molecules define a pathway required for neuron death in development and disease.Transforming growth factor beta (TGFbeta)-induced apoptosis: the rise & fall of BimCell cycle molecules and vertebrate neuron death: E2F at the hub.Men are but worms: neuronal cell death in C elegans and vertebrates.The MEK1/2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models.A B-Cell Superantigen Induces the Apoptosis of Murine and Human Malignant B Cells.Unlocking Pandora's box: personalising cancer cell death in non-small cell lung cancer.Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway.Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer.Garlic arrests MDA-MB-435 cancer cells in mitosis, phosphorylates the proapoptotic BH3-only protein BimEL and induces apoptosis.p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription.Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex.Loss of BH3-only protein Bim inhibits apoptosis of hemopoietic cells in the fetal liver and male germ cells but not neuronal cells in bcl-x-deficient miceSurvival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.Targeting anoikis resistance in prostate cancer metastasis.miRNAs stem cell reprogramming for neuronal induction and differentiation.Programmed cell death during neuronal development: the sympathetic neuron model.Rituximab-induced early and late signaling have opposite effects on dexamethasone-induced apoptosis in human follicular lymphoma cells.Overexpression of CREB protein protects from tunicamycin-induced apoptosis in various rat cell types.
P2860
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P2860
Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation
description
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2002
@ast
im Dezember 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/12/20)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/12/20)
@nl
наукова стаття, опублікована в грудні 2002
@uk
name
Nerve growth factor (NGF) down ...... ic activity by phosphorylation
@ast
Nerve growth factor (NGF) down ...... ic activity by phosphorylation
@en
Nerve growth factor (NGF) down ...... ic activity by phosphorylation
@nl
type
label
Nerve growth factor (NGF) down ...... ic activity by phosphorylation
@ast
Nerve growth factor (NGF) down ...... ic activity by phosphorylation
@en
Nerve growth factor (NGF) down ...... ic activity by phosphorylation
@nl
prefLabel
Nerve growth factor (NGF) down ...... ic activity by phosphorylation
@ast
Nerve growth factor (NGF) down ...... ic activity by phosphorylation
@en
Nerve growth factor (NGF) down ...... ic activity by phosphorylation
@nl
P2860
P3181
P356
P1476
Nerve growth factor (NGF) down ...... ic activity by phosphorylation
@en
P2093
Lloyd A. Greene
Subhas C. Biswas
P2860
P304
49511–49516
P3181
P356
10.1074/JBC.M208086200
P407
P577
2002-12-20T00:00:00Z