SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes
about
Increased insulin action in SKIP heterozygous knockout miceRegulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).SHIP2, a factor associated with diet-induced obesity and insulin sensitivity, attenuates FGF signaling in vivo.Discovery and development of small molecule SHIP phosphatase modulators.Mechanism of programmed obesity in intrauterine fetal growth restricted offspring: paradoxically enhanced appetite stimulation in fed and fasting states.Variants of insulin-signaling inhibitor genes in type 2 diabetes and related metabolic abnormalities.SHIP2 and its involvement in various diseases.Biochemistry and structure of phosphoinositide phosphatases.The importance of synthetic drugs for type 2 diabetes drug discovery.Molecular characterization, expression pattern, and association analysis with carcass traits of the porcine SHIP2 gene.Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2.Impact of lipid phosphatases SHIP2 and PTEN on the time- and Akt-isoform-specific amelioration of TNF-alpha-induced insulin resistance in 3T3-L1 adipocytes.PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes.Inhibition of SH2-domain containing inositol phosphatase 2 (SHIP2) in insulin producing INS1E cells improves insulin signal transduction and induces proliferation.Polymeric carrier-mediated intracellular delivery of phosphatidylinositol-3,4,5-trisphosphate to overcome insulin resistance.Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake.SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes.Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension.SH2-containing inositol 5'-phosphatase 2 selectively impairs hypothalamic insulin signalling and regulation of food intake in mice.Interaction of the WD40 domain of a myoinositol polyphosphate 5-phosphatase with SnRK1 links inositol, sugar, and stress signaling.INPPL1is associated with the metabolic syndrome in men with Type 1 diabetes, but not with diabetic nephropathy
P2860
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P2860
SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes
description
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
im Oktober 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/10/01)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/10/01)
@nl
наукова стаття, опублікована в жовтні 2001
@uk
مقالة علمية (نشرت في أكتوبر 2001)
@ar
name
SH2-containing inositol phosph ...... cogen synthesis in L6 myotubes
@ast
SH2-containing inositol phosph ...... cogen synthesis in L6 myotubes
@en
SH2-containing inositol phosph ...... cogen synthesis in L6 myotubes
@nl
type
label
SH2-containing inositol phosph ...... cogen synthesis in L6 myotubes
@ast
SH2-containing inositol phosph ...... cogen synthesis in L6 myotubes
@en
SH2-containing inositol phosph ...... cogen synthesis in L6 myotubes
@nl
prefLabel
SH2-containing inositol phosph ...... cogen synthesis in L6 myotubes
@ast
SH2-containing inositol phosph ...... cogen synthesis in L6 myotubes
@en
SH2-containing inositol phosph ...... cogen synthesis in L6 myotubes
@nl
P2093
P356
P1433
P1476
SH2-containing inositol phosph ...... cogen synthesis in L6 myotubes
@en
P2093
P2888
P304
P356
10.1007/S001250100645
P50
P577
2001-10-01T00:00:00Z
P5875
P6179
1040254940