about
Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activitySH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubesChronic nicotine exposure enhances insulin-induced mitogenic signaling via up-regulation of alpha7 nicotinic receptors in isolated rat aortic smooth muscle cellsMolecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signalingProgesterone inhibits glucose uptake by affecting diverse steps of insulin signaling in 3T3-L1 adipocytes.Flexible synthesis of poison-frog alkaloids of the 5,8-disubstituted indolizidine-class. II: Synthesis of (-)-209B, (-)-231C, (-)-233D, (-)-235B", (-)-221I, and an epimer of 193E and pharmacological effects at neuronal nicotinic acetylcholine receptLipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity.New insights into metabolic regulation via bifurcated function of estrogen receptor α.Role of orexin in the central regulation of glucose and energy homeostasis.Coenzyme Q10 prevents high glucose-induced oxidative stress in human umbilical vein endothelial cells.Tyrosine phosphorylation-dependent and -independent role of Shc in the regulation of IGF-1-induced mitogenesis and glycogen synthesis.Intracellular signalling pathways of okadaic acid leading to mitogenesis in Rat1 fibroblast overexpressing insulin receptors: okadaic acid regulates Shc phosphorylation by mechanisms independent of insulin.Relative involvement of Shc tyrosine 239/240 and tyrosine 317 on insulin induced mitogenic signaling in rat1 fibroblasts expressing insulin receptors.The inositol phosphatase SHIP2 negatively regulates insulin/IGF-I actions implicated in neuroprotection and memory function in mouse brain.The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation.Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2).Impact of lipid phosphatases SHIP2 and PTEN on the time- and Akt-isoform-specific amelioration of TNF-alpha-induced insulin resistance in 3T3-L1 adipocytes.Characteristics of signalling properties mediated by long-acting insulin analogue glargine and detemir in target cells of insulin.SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes.Glucosamine enhances platelet-derived growth factor-induced DNA synthesis via phosphatidylinositol 3-kinase pathway in rat aortic smooth muscle cells.Reduction of blood glucose level by orexins in fasting normal and streptozotocin-diabetic mice.Association of SH2-containing inositol phosphatase 2 with the insulin resistance of diabetic db/db mice.Protective effects of coenzyme Q10 against angiotensin II-induced oxidative stress in human umbilical vein endothelial cells.SH2-containing inositol 5'-phosphatase 2 selectively impairs hypothalamic insulin signalling and regulation of food intake in mice.Impact of SRC homology 2-containing inositol 5'-phosphatase 2 gene polymorphisms detected in a Japanese population on insulin signaling.Eplerenone prevented obesity-induced inflammasome activation and glucose intolerance.Impact of the liver-specific expression of SHIP2 (SH2-containing inositol 5'-phosphatase 2) on insulin signaling and glucose metabolism in mice.Impact of transgenic overexpression of SH2-containing inositol 5'-phosphatase 2 on glucose metabolism and insulin signaling in mice.Chronopathophysiological Implications of Orexin in Sleep Disturbances and Lifestyle-Related Disorders.Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice.Different impacts of acylated and non-acylated long-acting insulin analogs on neural functions in vitro and in vivo.Nighttime Administration of Nicotine Improves Hepatic Glucose Metabolism via the Hypothalamic Orexin System in Mice.Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice.PDGFRβ Regulates Adipose Tissue Expansion and Glucose Metabolism via Vascular Remodeling in Diet-Induced Obesity.Novel G423S mutation of human alpha7 nicotinic receptor promotes agonist-induced desensitization by a protein kinase C-dependent mechanism.Teneligliptin improves metabolic abnormalities in a mouse model of postmenopausal obesity.Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing.[Insulin resistance and cognitive function].Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP-1c Tg mice fed high-fat and high-fructose diet.Impact of central and peripheral estrogen treatment on anxiety and depression phenotypes in a mouse model of postmenopausal obesity
P50
Q24551012-5858F953-B124-45EC-A648-3972EB2F59DDQ28580460-DDC70180-5822-498C-B554-5278382EA036Q28581082-46B8DFF1-AFA0-4C24-9CEB-EE5467AD7C09Q28581883-80865AB5-0FEC-4F01-9E01-43F9F7550A68Q33523666-29A011B2-E1C3-4DB8-86C9-585B09DF9703Q36310658-6454CDDB-9F05-4C90-AE95-4F6FA47A47B8Q36536865-D94353FD-05F6-491C-9657-02F9764E41CDQ37333582-7A2E66DB-66BE-43A5-B669-1492019D082AQ37980323-94517A92-1D19-4209-A3D5-9C4BDBFE1B67Q40145750-12EF90BA-D2A0-40AD-9745-AAD42ADE6202Q40768067-0BA3C2EA-B6A2-42B8-9199-B28E55D3E8B0Q40909035-BE725081-D381-494B-B846-16B29A3C8517Q40995133-A4788841-2DCD-445E-B6B5-D05A1CD83B0EQ41847084-7CFCBB98-DC5C-4931-9F84-09DCCB174752Q41966425-C0BE2867-8111-4D51-A846-FDF57C6D7479Q42712766-FA4F9EFA-8DC4-47DA-AD90-2062CEEC8F87Q42806554-9C5382E3-85CC-416A-9053-A31BE2A0192BQ42811270-C18C2B2D-5E93-4ACB-9F35-A38B301ED088Q42831990-61DF1278-32E6-4B68-8502-AFDA283544D6Q43687617-BE401638-B22E-493A-8168-E1FA5A3A7DC5Q44080856-E7851449-AD6B-45E5-A591-6FD88FB0B8A1Q44080983-65D441B2-EE87-41D4-8759-EB6565EB44ABQ44707005-9E9F47F0-3C2D-4EF9-9CD9-2DEB652F2CB4Q44810785-6B7A352E-C5C2-433B-91F4-E5BD3D1D7699Q45248614-2969A58A-265A-482F-8ECC-903F46F35884Q46314243-0A6AD393-A9E0-45C3-B4F6-72F3A101EF0AQ46570529-686A42E3-223A-499B-BF4B-AFDFB28A4C3FQ46881275-2F1DD87D-5778-423B-B0DA-A8097FFFEF14Q47298845-684E32D9-8B0D-4775-A562-F4D94ADC4948Q47799179-5E6834AB-29DF-43D9-B8F1-2656E3F14BE7Q47884566-F316EC36-B132-4E84-9EDA-026E4E94133FQ47925016-C60FB2EA-71CF-448D-8A89-D7DA32D94CD2Q48028308-ACE9126A-BC70-417D-98C5-D121FE1A0A3AQ48340024-548033D8-9975-4C95-A803-9981A23C19A9Q50642235-54BCB8E4-0198-4C5F-AF42-9A2C90E0EB2FQ50996208-938A3F6F-7F32-4BD4-8697-E57C10C654E8Q52561631-610903C9-05F8-4CAA-BEFC-1CEAF0506C8DQ54355131-895055E4-E48E-43F4-A570-F7D3C7B94CD5Q54753378-16C89DFD-81EB-40DB-9125-2B99883E5058Q60932302-F13584FD-9A22-42D9-ACD9-DD644B2CF9DC
P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Tsutomu Wada
@ast
Tsutomu Wada
@en
Tsutomu Wada
@es
Tsutomu Wada
@nl
type
label
Tsutomu Wada
@ast
Tsutomu Wada
@en
Tsutomu Wada
@es
Tsutomu Wada
@nl
prefLabel
Tsutomu Wada
@ast
Tsutomu Wada
@en
Tsutomu Wada
@es
Tsutomu Wada
@nl
P106
P31
P496
0000-0001-5819-8556