WAY-163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole], a novel 5-hydroxytryptamine 2C receptor-selective agonist with anorectic activity
about
Pharmacological targeting of the serotonergic system for the treatment of obesitySerotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorderPSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptorsThe Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsThe potential use of selective 5-HT2C agonists in treating obesity.Selective serotonin 5-HT(2C) receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. sucrose-associated cues.We Need 2C but Not 2B: Developing Serotonin 2C (5-HT2C) Receptor Agonists for the Treatment of CNS Disorders.Innovative approaches for the development of antidepressant drugs: current and future strategiesSynergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction.Investigational therapies in the treatment of obesity.Pharmacological profile of the 5-HT(2C) receptor agonist WAY-163909; therapeutic potential in multiple indications.Serotonin2C Receptors and the Motor Control of Oral ActivityIncubation of cocaine cue reactivity associates with neuroadaptations in the cortical serotonin (5-HT) 5-HT2C receptor (5-HT2CR) systemEmerging drugs for obesity therapy.New therapeutic potential for psychoactive natural products.Imaging evaluation of 5HT2C agonists, [(11)C]WAY-163909 and [(11)C]vabicaserin, formed by Pictet-Spengler cyclizationA novel aminotetralin-type serotonin (5-HT) 2C receptor-specific agonist and 5-HT2A competitive antagonist/5-HT2B inverse agonist with preclinical efficacy for psychoses.5-HT2C receptor modulators: a patent survey.The role of serotonin in the NMDA receptor antagonist models of psychosis and cognitive impairment.Multiple controls exerted by 5-HT2C receptors upon basal ganglia function: from physiology to pathophysiology.New molecular targets in the pathophysiology of obesity and available treatment options under investigation.Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys.3,4-Methylenedioxymethamphetamine Increases Affiliative Behaviors in Squirrel Monkeys in a Serotonin 2A Receptor-Dependent Manner.A short history of the 5-HT2C receptor: from the choroid plexus to depression, obesity and addiction treatment.Discovery and development of 5-HT(₂C) receptor agonists for obesity: is there light at the end of the tunnel?Effects of a Serotonin 2C Agonist and a 2A Antagonist on Actigraphy-Based Sleep Parameters Disrupted by Methamphetamine Self-Administration in Rhesus Monkeys.Synthesis and Structure-Activity Relationships of Tool Compounds Based on WAY163909, a 5-HT2C Receptor Agonist.Repeated administration of 5-hydroxytryptamine 2C agonist MK212 produces a sensitization effect of antipsychotic activity.Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice.Serotonin 5-HT Receptor Activation Suppresses Binge Intake and the Reinforcing and Motivational Properties of High-Fat Food
P2860
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P2860
WAY-163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole], a novel 5-hydroxytryptamine 2C receptor-selective agonist with anorectic activity
description
2005 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im Mai 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/05/01)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/05/01)
@nl
наукова стаття, опублікована в травні 2005
@uk
مقالة علمية (نشرت في مايو 2005)
@ar
name
WAY-163909 [(7bR, 10aR)-1,2,3, ...... gonist with anorectic activity
@ast
WAY-163909 [(7bR, 10aR)-1,2,3, ...... gonist with anorectic activity
@en
WAY-163909 [(7bR, 10aR)-1,2,3, ...... gonist with anorectic activity
@nl
type
label
WAY-163909 [(7bR, 10aR)-1,2,3, ...... gonist with anorectic activity
@ast
WAY-163909 [(7bR, 10aR)-1,2,3, ...... gonist with anorectic activity
@en
WAY-163909 [(7bR, 10aR)-1,2,3, ...... gonist with anorectic activity
@nl
prefLabel
WAY-163909 [(7bR, 10aR)-1,2,3, ...... gonist with anorectic activity
@ast
WAY-163909 [(7bR, 10aR)-1,2,3, ...... gonist with anorectic activity
@en
WAY-163909 [(7bR, 10aR)-1,2,3, ...... gonist with anorectic activity
@nl
P2093
P356
P1476
WAY-163909 [(7bR, 10aR)-1,2,3, ...... gonist with anorectic activity
@en
P2093
Annmarie L. Sabb
Boyd L. Harrison
Eugenia Shukhina
Gary Stack
Hossein Mazandarani
Jean Zhang
John Dunlop
Lee Schechter
Robert L. Vogel
Sachin Kalgaonker
P304
P356
10.1124/JPET.104.075382
P407
P577
2005-05-01T00:00:00Z