Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction. - Wikidata - awgldk - TriplyDB

Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction.

Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction.

http://www.wikidata.org/entity/Q36540945

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Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorder Individual Differences in Impulsive Action Reflect Variation in the Cortical Serotonin 5-HT2A Receptor System Rapid-response impulsivity: definitions, measurement issues, and clinical implications Elevated Expression of Serotonin 5-HT(2A) Receptors in the Rat Ventral Tegmental Area Enhances Vulnerability to the Behavioral Effects of Cocaine Functional status of the serotonin 5-HT2C receptor (5-HT2CR) drives interlocked phenotypes that precipitate relapse-like behaviors in cocaine dependence Evaluation of structural effects on 5-HT(2A) receptor antagonism by aporphines: identification of a new aporphine with 5-HT(2A) antagonist activity.Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans Serotonin at the nexus of impulsivity and cue reactivity in cocaine addiction.Role for serotonin2A (5-HT2A) and 2C (5-HT2C) receptors in experimental absence seizures.Serotonin-2C and -2a receptor co-expression on cells in the rat medial prefrontal cortex.Serotonin (5-HT) 5-HT2A Receptor (5-HT2AR):5-HT2CR Imbalance in Medial Prefrontal Cortex Associates with Motor Impulsivity.Incubation of cocaine cue reactivity associates with neuroadaptations in the cortical serotonin (5-HT) 5-HT2C receptor (5-HT2CR) system Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior.Molecular pharmacology and ligand docking studies reveal a single amino acid difference between mouse and human serotonin 5-HT2A receptors that impacts behavioral translation of novel 4-phenyl-2-dimethylaminotetralin ligands Variation within the serotonin (5-HT) 5-HT₂C receptor system aligns with vulnerability to cocaine cue reactivity A novel aminotetralin-type serotonin (5-HT) 2C receptor-specific agonist and 5-HT2A competitive antagonist/5-HT2B inverse agonist with preclinical efficacy for psychoses.Designing modulators of 5-hydroxytryptamine signaling to treat abuse disorders.Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys.A short history of the 5-HT2C receptor: from the choroid plexus to depression, obesity and addiction treatment.Celebrating serotonin.Repeated 7-Day Treatment with the 5-HT2C Agonist Lorcaserin or the 5-HT2A Antagonist Pimavanserin Alone or in Combination Fails to Reduce Cocaine vs Food Choice in Male Rhesus Monkeys.Lorcaserin Suppresses Oxycodone Self-Administration and Relapse Vulnerability in Rats.Inhibition of cocaine and 3,4-methylenedioxypyrovalerone (MDPV) self-administration by lorcaserin is mediated by 5-HT2C receptors in rats.Effects of a Serotonin 2C Agonist and a 2A Antagonist on Actigraphy-Based Sleep Parameters Disrupted by Methamphetamine Self-Administration in Rhesus Monkeys.Effects of 5-HT1A, 5-HT2A and 5-HT2C receptor agonists and antagonists on responding for a conditioned reinforcer and its enhancement by methylphenidate.Synthesis and Structure-Activity Relationships of Tool Compounds Based on WAY163909, a 5-HT2C Receptor Agonist.Novel Bivalent 5-HT2A Receptor Antagonists Exhibit High Affinity and Potency in Vitro and Efficacy in Vivo.PPARγ agonism attenuates cocaine cue reactivity.Differences in trait impulsivity do not bias the response to pharmacological drug challenge in the rat five-choice serial reaction time task.Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction

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P2860

Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction.

http://www.wikidata.org/entity/Q36540945

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Synergism between a serotonin ...... peutics for cocaine addiction.

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ACS Chemical Neuroscience

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Synergism between a serotonin ...... peutics for cocaine addiction.

@en

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Cheryl S Watson

http://www.w3.org/2001/XMLSchema#string

F Gerard Moeller

http://www.w3.org/2001/XMLSchema#string

Kathryn A Cunningham

http://www.w3.org/2001/XMLSchema#string

Kenner C Rice

http://www.w3.org/2001/XMLSchema#string

Marcy J Bubar

http://www.w3.org/2001/XMLSchema#string

Noelle C Anastasio

http://www.w3.org/2001/XMLSchema#string

Robert G Fox

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Sarah E Swinford

http://www.w3.org/2001/XMLSchema#string

Scott R Gilbertson

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Sharon Rosenzweig-Lipson

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P2860

The dopamine d1-d2 receptor heteromer in striatal medium spiny neurons: evidence for a third distinct neuronal pathway in Basal Ganglia

A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers.

Neurocircuitry of addiction

Molecular, pharmacological and functional diversity of 5-HT receptors

WAY-163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole], a novel 5-hydroxytryptamine 2C receptor-selective agonist with anorectic activity

A bivalent ligand (KMN-21) antagonist for mu/kappa heterodimeric opioid receptors

M-100907 (Aventis).

The impact of impulsivity on cocaine use and retention in treatment.

The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry.

Differential effects of the 5-HT(2A) receptor antagonist M100907 and the 5-HT(2C) receptor antagonist SB242084 on cocaine-induced locomotor activity, cocaine self-administration and cocaine-induced reinstatement of responding.

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110-121

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10.1021/CN300072U

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1

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4

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