The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease
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FKBP51 and FKBP52 in signaling and diseaseNuclear tau, a key player in neuronal DNA protection.Pin1 inhibition activates cyclin D and produces neurodegenerative pathologyMitochondrial oxidative stress causes hyperphosphorylation of tau.Peripheral blood mononuclear cells as a laboratory to study dementia in the elderly.A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditionsγ-Aminobutyric acid type A (GABAA) receptor activation modulates tau phosphorylation.Ectosomes: a new mechanism for non-exosomal secretion of tau protein.Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons.Tau Hyperphosphorylation and Oxidative Stress, a Critical Vicious Circle in Neurodegenerative Tauopathies?Novel modulators of amyloid-beta precursor protein processing.AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo.The role of tau in neurodegenerationLoss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatinTau dephosphorylation and microfilaments disruption are upstream events of the anti-proliferative effects of DADS in SH-SY5Y cellsPeptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the rel proteins in the nuclear factor-kappaB family.Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease.Bending tau into shape: the emerging role of peptidyl-prolyl isomerases in tauopathiesPeptidyl-prolyl cis-trans isomerase Pin1 in ageing, cancer and Alzheimer disease.Invited review: Animal models of tauopathies and their implications for research/translation into the clinic.Effect of Pin1 or microtubule binding on dephosphorylation of FTDP-17 mutant TauNeuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies.The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion modelPin1, a new player in the fate of HIF-1α degradation: an hypothetical mechanism inside vascular damage as Alzheimer's disease risk factor.Yeast as a model system to study tau biology.Juglone inactivates cysteine-rich proteins required for progression through mitosis.Primate retinal cones express phosphorylated tau associated with neuronal degeneration yet survive in old age.A small molecule Pin1 inhibitor blocks NF-κB signaling in prostate cancer cells.Chronic traumatic encephalopathy-integration of canonical traumatic brain injury secondary injury mechanisms with tau pathology.Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration.Pin1 Promotes Regulated Necrosis Induced by Glutamate in Rat Retinal Neurons via CAST/Calpain2 Pathway.Pin1 mediates Aβ42-induced dendritic spine loss.Electrochemical investigations of Tau protein phosphorylations and interactions with Pin1.The Involvement of Aβ42 and Tau in Nucleolar and Protein Synthesis Machinery Dysfunction
P2860
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P2860
The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease
description
2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2006
@ast
im Juli 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/07/14)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/07/14)
@nl
наукова стаття, опублікована в липні 2006
@uk
name
The peptidylprolyl cis/trans-i ...... m related to Alzheimer disease
@ast
The peptidylprolyl cis/trans-i ...... m related to Alzheimer disease
@en
The peptidylprolyl cis/trans-i ...... m related to Alzheimer disease
@nl
type
label
The peptidylprolyl cis/trans-i ...... m related to Alzheimer disease
@ast
The peptidylprolyl cis/trans-i ...... m related to Alzheimer disease
@en
The peptidylprolyl cis/trans-i ...... m related to Alzheimer disease
@nl
prefLabel
The peptidylprolyl cis/trans-i ...... m related to Alzheimer disease
@ast
The peptidylprolyl cis/trans-i ...... m related to Alzheimer disease
@en
The peptidylprolyl cis/trans-i ...... m related to Alzheimer disease
@nl
P2860
P50
P3181
P356
P1476
The peptidylprolyl cis/trans-i ...... m related to Alzheimer disease
@en
P2093
Séverine Bégard
P2860
P304
19296-19304
P3181
P356
10.1074/JBC.M601849200
P407
P577
2006-05-03T00:00:00Z