Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells
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Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cellsPancreatic β Cell Mass DeathEndoplasmic reticulum stress and type 2 diabetesKinase Signaling in Apoptosis Induced by Saturated Fatty Acids in Pancreatic β-CellsProtein kinase C epsilon activates lens mitochondrial cytochrome c oxidase subunit IV during hypoxiaInterleukin-1 beta induces posttranslational carboxymethylation and alterations in subnuclear distribution of lamin B in insulin-secreting RINm5F cellsTRB3 is involved in free fatty acid-induced INS-1-derived cell apoptosis via the protein kinase C δ pathwayPKCdelta blues for the beta-cellAn islet in distress: β cell failure in type 2 diabetes.Palmitate induced IL-6 and MCP-1 expression in human bladder smooth muscle cells provides a link between diabetes and urinary tract infectionsPemetrexed induces S-phase arrest and apoptosis via a deregulated activation of Akt signaling pathway.Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1.Stearate preferentially induces apoptosis in human breast cancer cells.Herpes simplex virus type 1 infection induces activation and recruitment of protein kinase C to the nuclear membrane and increased phosphorylation of lamin B.Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance.Exogenous insulin enhances glucose-stimulated insulin response in healthy humans independent of changes in free fatty acids.p38 MAPK Is Activated but Does Not Play a Key Role during Apoptosis Induction by Saturated Fatty Acid in Human Pancreatic β-Cells.Induction of autophagy by palmitic acid via protein kinase C-mediated signaling pathway independent of mTOR (mammalian target of rapamycin).Protein kinase C as a stress sensor.Monounsaturated fatty acids prevent the aversive effects of obesity on locomotion, brain activity, and sleep behaviorSaturated fatty acids induce post-transcriptional regulation of HAMP mRNA via AU-rich element-binding protein, human antigen R (HuR).RNASET2 is required for ROS propagation during oxidative stress-mediated cell death.Granulocyte colony-stimulating factor (G-CSF): A saturated fatty acid-induced myokine with insulin-desensitizing properties in humans.Protein kinase C function in muscle, liver, and beta-cells and its therapeutic implications for type 2 diabetes.MicroRNA-24/MODY gene regulatory pathway mediates pancreatic β-cell dysfunctionProtein kinase C delta-mediated processes in cholecystokinin-8-stimulated pancreatic aciniAs a matter of fat.Untangling the interplay of genetic and metabolic influences on beta-cell function: Examples of potential therapeutic implications involving TCF7L2 and FFAR1.The Glucotoxicity Protecting Effect of Ezetimibe in Pancreatic Beta Cells via Inhibition of CD36.In Vitro Effect of Fatty Acids Identified in the Plasma of Obese Adolescents on the Function of Pancreatic β-CellsExendin-4 protects pancreatic beta cells from palmitate-induced apoptosis by interfering with GPR40 and the MKK4/7 stress kinase signalling pathway.Inhibitory effect of unsaturated fatty acids on saturated fatty acid-induced apoptosis in human pancreatic β-cells: activation of caspases and ER stress induction.ATP-citrate lyase reduction mediates palmitate-induced apoptosis in pancreatic beta cells.Roles of PKC isoforms in the induction of apoptosis elicited by aberrant Ras.Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells.Stevioside Counteracts Beta-Cell Lipotoxicity without Affecting Acetyl CoA Carboxylase.Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells.The p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells.Overexpression of kinase-negative protein kinase Cdelta in pancreatic beta-cells protects mice from diet-induced glucose intolerance and beta-cell dysfunction.On a sugary-relationship between caspases and lamins.
P2860
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P2860
Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells
description
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im April 2003 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2003/04/01)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/04/01)
@nl
наукова стаття, опублікована у квітні 2003
@uk
مقالة علمية (نشرت في أبريل 2003)
@ar
name
Protein kinase C delta activat ...... sis of insulin-secreting cells
@ast
Protein kinase C delta activat ...... sis of insulin-secreting cells
@en
Protein kinase C delta activat ...... sis of insulin-secreting cells
@nl
type
label
Protein kinase C delta activat ...... sis of insulin-secreting cells
@ast
Protein kinase C delta activat ...... sis of insulin-secreting cells
@en
Protein kinase C delta activat ...... sis of insulin-secreting cells
@nl
prefLabel
Protein kinase C delta activat ...... sis of insulin-secreting cells
@ast
Protein kinase C delta activat ...... sis of insulin-secreting cells
@en
Protein kinase C delta activat ...... sis of insulin-secreting cells
@nl
P2093
P50
P921
P3181
P1433
P1476
Protein kinase C delta activat ...... sis of insulin-secreting cells
@en
P2093
Heide Brandhorst
Johannes Rieger
Katrin Eitel
Mathias D. Brendel
Monika Kellerer
Reinhard G. Bretzel
P304
P3181
P356
10.2337/DIABETES.52.4.991
P407
P577
2003-04-01T00:00:00Z