Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells.
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Differential regulation of endoplasmic reticulum stress by protein tyrosine phosphatase 1B and T cell protein tyrosine phosphataseEndoplasmic reticulum stress and type 2 diabetesEndoplasmic reticulum redox state is not perturbed by pharmacological or pathological endoplasmic reticulum stress in live pancreatic β-cellsRole of ceramide in diabetes mellitus: evidence and mechanisms.It's not how fat you are, it's what you do with it that countsGlucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase.Reconstruct modular phenotype-specific gene networks by knowledge-driven matrix factorizationPDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppressionLack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death.Group VIA phospholipase A2 mitigates palmitate-induced β-cell mitochondrial injury and apoptosisEndoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin.Glucolipotoxicity of the pancreatic beta cell.Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention.Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78Valproate pretreatment protects pancreatic β-cells from palmitate-induced ER stress and apoptosis by inhibiting glycogen synthase kinase-3βα-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytesReduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells.Distinct gene expression profiles characterize cellular responses to palmitate and oleate.Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway.OASIS/CREB3L1 induces expression of genes involved in extracellular matrix production but not classical endoplasmic reticulum stress response genes in pancreatic beta-cells.Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humansInvolvement of oxygen-regulated protein 150 in AMP-activated protein kinase-mediated alleviation of lipid-induced endoplasmic reticulum stress.Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization.DNAJB3/HSP-40 cochaperone is downregulated in obese humans and is restored by physical exercise.Shiga toxins induce autophagic cell death in intestinal epithelial cells via the endoplasmic reticulum stress pathway.p38 MAPK Is Activated but Does Not Play a Key Role during Apoptosis Induction by Saturated Fatty Acid in Human Pancreatic β-Cells.Update on the protective molecular pathways improving pancreatic beta-cell dysfunctionChronic inflammation role in the obesity-diabetes association: a case-cohort study.25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway.Deregulation of XBP1 expression contributes to myocardial vascular endothelial growth factor-A expression and angiogenesis during cardiac hypertrophy in vivo.Endoplasmic reticulum stress: another link between obesity and insulin resistance/inflammation?TGF-β superfamily member Nodal stimulates human β-cell proliferation while maintaining cellular viability.Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis.Calcium efflux from the endoplasmic reticulum leads to β-cell death.The p21-activated kinase (PAK1) is involved in diet-induced beta cell mass expansion and survival in mice and human islets.Integration of ER stress, oxidative stress and the inflammatory response in health and diseaseHigh-density lipoprotein, beta cells, and diabetes .In Vitro Effect of Fatty Acids Identified in the Plasma of Obese Adolescents on the Function of Pancreatic β-CellsUPR in palmitate-treated pancreatic beta-cells is not affected by altering oxidation of the fatty acid
P2860
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P2860
Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Differential activation of ER ...... cids in pancreatic beta-cells.
@en
type
label
Differential activation of ER ...... cids in pancreatic beta-cells.
@en
prefLabel
Differential activation of ER ...... cids in pancreatic beta-cells.
@en
P2093
P2860
P1476
Differential activation of ER ...... cids in pancreatic beta-cells.
@en
P2093
Allen Volchuk
George Bikopoulos
Maria Rozakis-Adcock
P2860
P304
P356
10.1152/AJPENDO.00478.2007
P577
2008-01-15T00:00:00Z