Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor
about
The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cellsT cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expressionSystematic identification of regulatory proteins critical for T-cell activationSpecific activation of leukocyte beta2 integrins lymphocyte function-associated antigen-1 and Mac-1 by chemokines mediated by distinct pathways via the alpha subunit cytoplasmic domainsFYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cellsFunctional association between SLAP-130 and SLP-76 in Jurkat T cellsEvidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signalingCloning of ACP33 as a novel intracellular ligand of CD4Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signalingThe influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activationT cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in miceRegulation of FynT function by dual domain docking on PAG/CbpTyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphataseDistinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytesUnc119, a novel activator of Lck/Fyn, is essential for T cell activationMolecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signalingThe human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylationMolecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytesA Zn2+ ion links the cytoplasmic tail of CD4 and the N-terminal region of LckThe tyrosine kinase Lck is a positive regulator of the mitochondrial apoptosis pathway by controlling Bak expressionDemonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitroHuman homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytesThe kinase, SH3, and SH2 domains of Lck play critical roles in T-cell activation after ZAP-70 membrane localizationPositive and negative regulation of T-cell activation through kinases and phosphatasesIdentification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFATGRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulationThe T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lckAutoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residueDistinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor functionL-selectin activates the Ras pathway via the tyrosine kinase p56lckTyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signalingRAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytesSyk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complexT cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T)Signalling pathways induced by protease-activated receptors and integrins in T cellsSignaling advances from immunogenetics to immunogenomicsMolecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling UnitsAurora A drives early signalling and vesicle dynamics during T-cell activation.Transcriptional Activation of the Interleukin-2 Promoter by Hepatitis C Virus Core ProteinT Cell Receptors are Structures Capable of Initiating Signaling in the Absence of Large Conformational Rearrangements
P2860
Q21090492-8E89EED5-0100-4365-8683-234C14B254D3Q21146439-8A278F59-5D72-42B6-A2A5-5399C43307DAQ21245890-522F5358-F574-437C-A300-A98232A797A2Q22009172-14AB3CFF-5CE2-44BE-BFE3-A73815ACB25FQ22010396-E07EE6DE-F493-434A-92EA-40EE37F95660Q22253173-B1065CB7-BC95-4EA1-9E86-A13EE35498FDQ22254040-DA740CCE-C89F-4975-8BBE-96AE795CAD65Q24290610-7A1CC5A6-F337-4279-8DC9-62779963993DQ24291874-9510BB0A-DDB4-421A-A790-5FF56E5ACB10Q24296660-BE191D92-CE9B-4571-B789-ADB04DD0C3E6Q24297041-65D7132F-CD06-4CA2-9C8D-908B86F71A97Q24302122-71466D57-86B5-4810-9F70-4AE41181BEB2Q24304981-E928D461-E9C0-48A8-BE82-AA2B7F6F5F6EQ24305363-217DCD38-7250-4B91-B630-FBC7AAF7A34DQ24306892-809B5BCA-48E6-4EBF-9010-454F58DFC443Q24308231-BC284DFD-67E1-434B-8023-391F1F85E03DQ24313145-A4D2C5E6-BC57-49D1-8F8D-9D09D70EAC2DQ24313200-9451C3D4-FEED-473C-A9F4-250AB744BDFDQ24316020-E8388BC5-2776-4DE5-A77D-8E987BFC83FFQ24317331-63AB91A7-7B80-43C1-9A1C-87A55E65103AQ24318630-14F13925-09D6-4FB2-9BC2-5ECC88568EE7Q24319836-6F543EE8-DB4A-45B4-9DF4-AB8CB8A04BFFQ24324202-E413C072-62F4-4BAA-9B52-1A08EB5627F5Q24535649-BAB58847-F058-4B5F-A7C8-908F5BA5F576Q24550948-A7628E48-2EA9-4226-805C-7637AD987002Q24611910-1F3DEB90-FC9E-4948-B9C1-23E02F65100FQ24613024-536C8F01-525B-43D1-BF19-D70FE6295370Q24630403-3D37BAC8-021B-47F3-ACDE-7BA87D538037Q24648638-505B7563-ED53-413F-8D26-0C9E35BC10FCQ24653696-2696B98D-75D1-417E-A7CC-300A23E3138FQ24669865-4470945B-FAEA-438D-BE0B-DB0BE186ABFCQ24669953-BFE0EE6D-EF4C-4E11-8C76-6F3FBAC411DCQ24678927-A0A7BFA5-E005-4A83-9EC9-695C83F32A83Q24680262-A0835EBD-C8B2-4CBC-BE76-D30AC37E1D94Q24682815-DFD1194D-853A-4177-A6A3-F71356E7B0C5Q24793529-32D90989-440C-4972-B44F-D474811AF4ABQ26744973-8980C199-88CD-4D60-AE46-DAD486CF7ED1Q27318948-002307C9-81DF-4E4D-8C8B-235E12E44FFEQ27469762-A16601ED-99CD-4275-BD5C-6B61F025A436Q27676807-55EF2596-200E-45D1-B540-9E17D8A1D30A
P2860
Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor
description
1992 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1992
@ast
im August 1992 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1992/08/21)
@sk
vědecký článek publikovaný v roce 1992
@cs
wetenschappelijk artikel (gepubliceerd op 1992/08/21)
@nl
наукова стаття, опублікована в серпні 1992
@uk
مقالة علمية (نشرت في 21-8-1992)
@ar
name
Genetic evidence for the invol ...... gh the T cell antigen receptor
@ast
Genetic evidence for the invol ...... gh the T cell antigen receptor
@en
Genetic evidence for the invol ...... gh the T cell antigen receptor
@nl
type
label
Genetic evidence for the invol ...... gh the T cell antigen receptor
@ast
Genetic evidence for the invol ...... gh the T cell antigen receptor
@en
Genetic evidence for the invol ...... gh the T cell antigen receptor
@nl
prefLabel
Genetic evidence for the invol ...... gh the T cell antigen receptor
@ast
Genetic evidence for the invol ...... gh the T cell antigen receptor
@en
Genetic evidence for the invol ...... gh the T cell antigen receptor
@nl
P3181
P1433
P1476
Genetic evidence for the invol ...... gh the T cell antigen receptor
@en
P2093
D. B. Straus
P304
P3181
P356
10.1016/0092-8674(92)90428-F
P407
P577
1992-08-21T00:00:00Z