RAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes
about
Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402Leupaxin is a novel LIM domain protein that forms a complex with PYK2A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signalHuman immunodeficiency virus tat modulates the Flk-1/KDR receptor, mitogen-activated protein kinases, and components of focal adhesion in Kaposi's sarcoma cells.A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT.Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and SykPyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration.Involvement of proline-rich tyrosine kinase 2 in platelet activation: tyrosine phosphorylation mostly dependent on alphaIIbbeta3 integrin and protein kinase C, translocation to the cytoskeleton and association with Shc through Grb2.RETRACTED: Functional activation of proline-rich tyrosine kinase2 (PYK2) in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF.Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7Ralpha.Functions of the FAK family kinases in T cells: beyond actin cytoskeletal rearrangement.Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fateRegulation of microtubule-organizing center orientation and actomyosin cytoskeleton rearrangement during immune interactions.Visualization of signaling pathways and cortical cytoskeleton in cytolytic and noncytolytic natural killer cell immune synapses.Differential expression of FAK and Pyk2 in metastatic and non-metastatic EL4 lymphoma cell linesCritical role of the carboxyl terminus of proline-rich tyrosine kinase (Pyk2) in the activation of human neutrophils by tumor necrosis factor: separation of signals for the respiratory burst and degranulationThe interaction of activated integrin lymphocyte function-associated antigen 1 with ligand intercellular adhesion molecule 1 induces activation and redistribution of focal adhesion kinase and proline-rich tyrosine kinase 2 in T lymphocytes.Positive and negative regulation by SLP-76/ADAP and Pyk2 of chemokine-stimulated T-lymphocyte adhesion mediated by integrin α4β1Separation and characterization of the activated pool of colony-stimulating factor 1 receptor forming distinct multimeric complexes with signalling molecules in macrophagesInteraction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells.The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast growth factor receptor 3 activation.The beta1 and beta3 integrins promote T cell receptor-mediated cytotoxic T lymphocyte activation.ANG II and LPA induce Pyk2 tyrosine phosphorylation in intestinal epithelial cells: role of Ca2+, PKC, and Rho kinase.The tyrosine kinase PYK-2/RAFTK regulates natural killer (NK) cell cytotoxic response, and is translocated and activated upon specific target cell recognition and killingInteractions between two cytoskeleton-associated tyrosine kinases: calcium-dependent tyrosine kinase and focal adhesion tyrosine kinase.Activation of protein-tyrosine kinase Pyk2 is downstream of Syk in FcepsilonRI signaling.Regulation of the tyrosine kinase Pyk2 by calcium is through production of reactive oxygen species in cytotoxic T lymphocytes.Cholecystokinin activates PYK2/CAKbeta by a phospholipase C-dependent mechanism and its association with the mitogen-activated protein kinase signaling pathway in pancreatic acinar cells.The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN.The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems.Inhibition of osteoclast function by adenovirus expressing antisense protein-tyrosine kinase 2.Regulation of tyrosine phosphorylation of PYK2 in vascular endothelial cells by lysophosphatidylcholine.RAFTK/Pyk2 involvement in platelet activation is mediated by phosphoinositide 3-kinase.Beta 1/beta 3 integrin ligation is uncoupled from ERK1/ERK2 activation in cytotoxic T lymphocytes.Key role of proline-rich tyrosine kinase 2 in interleukin-8 (CXCL8/IL-8)-mediated human neutrophil chemotaxis.Tyrosine phosphorylation of beta3 integrin provides a binding site for Pyk2.Identification of a new Pyk2 isoform implicated in chemokine and antigen receptor signaling.Differential regulation of FAK+ and PYK2/Cakbeta, two related tyrosine kinases, in rat hippocampal slices: effects of LPA, carbachol, depolarization and hyperosmolarity.Pyk2 Controls Integrin-Dependent CTL Migration through Regulation of De-Adhesion.
P2860
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P2860
RAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes
description
1997 nî lūn-bûn
@nan
1997 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մարտին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
RAFTK, a novel member of the f ...... vation of mature T lymphocytes
@ast
RAFTK, a novel member of the f ...... vation of mature T lymphocytes
@en
RAFTK, a novel member of the f ...... vation of mature T lymphocytes
@nl
type
label
RAFTK, a novel member of the f ...... vation of mature T lymphocytes
@ast
RAFTK, a novel member of the f ...... vation of mature T lymphocytes
@en
RAFTK, a novel member of the f ...... vation of mature T lymphocytes
@nl
prefLabel
RAFTK, a novel member of the f ...... vation of mature T lymphocytes
@ast
RAFTK, a novel member of the f ...... vation of mature T lymphocytes
@en
RAFTK, a novel member of the f ...... vation of mature T lymphocytes
@nl
P2093
P2860
P356
P1476
RAFTK, a novel member of the f ...... vation of mature T lymphocytes
@en
P2093
P2860
P304
P356
10.1084/JEM.185.6.1055
P407
P577
1997-03-17T00:00:00Z