TIGAR is required for efficient intestinal regeneration and tumorigenesis
about
Expanding antitumor therapeutic windows by targeting cancer-specific nicotinamide adenine dinucleotide phosphate-biogenesis pathwaysSmall molecule compounds targeting the p53 pathway: are we finally making progress?PCK2 activation mediates an adaptive response to glucose depletion in lung cancerHMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell nicheTP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.Targeting MUC1-C is synergistic with bortezomib in downregulating TIGAR and inducing ROS-mediated myeloma cell death.Regulation of the pentose phosphate pathway in cancerPla2g16 phospholipase mediates gain-of-function activities of mutant p53.Ferroptosis as a p53-mediated activity during tumour suppressionFunctional annotation of colon cancer risk SNPs.Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells.TAp73 promotes anabolismAnalysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function.Fatty acid carbon is essential for dNTP synthesis in endothelial cellsThe p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer DevelopmentThe return of metabolism: biochemistry and physiology of the pentose phosphate pathwayMicrotargeting cancer metabolism: opening new therapeutic windows based on lipid metabolismp73 regulates basal and starvation-induced liver metabolism in vivo.Identification of the TP53-induced glycolysis and apoptosis regulator in various stages of colorectal cancer patients.Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma.TP53 mutation, mitochondria and cancer.Metabolic regulation by p53 family members.Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responsesp53 and regulation of tumor metabolism.TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemiaAcetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression.Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer.To be, or not to be: functional dilemma of p53 metabolic regulation.Understanding the non-canonical pathways involved in p53-mediated tumor suppression.Stress eating and tuning out: cancer cells re-wire metabolism to counter stress.Dealing with hunger: Metabolic stress responses in tumors.Antitumor mechanisms when pRb and p53 are genetically inactivated.Tumor-Suppressor Functions of the TP53 Pathway.p53- and p73-independent activation of TIGAR expression in vivo.Metabolic Regulation of Apoptosis in Cancer.The p53 family orchestrates the regulation of metabolism: physiological regulation and implications for cancer therapy.ROS in Cancer: The Burning Question.Epithelial-mesenchymal transition and nuclear β-catenin induced by conditional intestinal disruption of Cdh1 with Apc is E-cadherin EC1 domain dependent.Exploiting tumour addiction with a serine and glycine-free diet.
P2860
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P2860
TIGAR is required for efficient intestinal regeneration and tumorigenesis
description
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2013
@ast
im Juni 2013 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2013/06/10)
@sk
vědecký článek publikovaný v roce 2013
@cs
wetenschappelijk artikel (gepubliceerd op 2013/06/10)
@nl
наукова стаття, опублікована в червні 2013
@uk
مقالة علمية (نشرت في 10-6-2013)
@ar
name
TIGAR is required for efficient intestinal regeneration and tumorigenesis
@ast
TIGAR is required for efficient intestinal regeneration and tumorigenesis
@en
TIGAR is required for efficient intestinal regeneration and tumorigenesis
@nl
type
label
TIGAR is required for efficient intestinal regeneration and tumorigenesis
@ast
TIGAR is required for efficient intestinal regeneration and tumorigenesis
@en
TIGAR is required for efficient intestinal regeneration and tumorigenesis
@nl
prefLabel
TIGAR is required for efficient intestinal regeneration and tumorigenesis
@ast
TIGAR is required for efficient intestinal regeneration and tumorigenesis
@en
TIGAR is required for efficient intestinal regeneration and tumorigenesis
@nl
P2093
P2860
P50
P3181
P1433
P1476
TIGAR is required for efficient intestinal regeneration and tumorigenesis
@en
P2093
Colin Nixon
Douglas Strathdee
Eric C. Cheung
Karen H. Vousden
Rachel A. Ridgway
Wendy Lambie
P2860
P304
P3181
P356
10.1016/J.DEVCEL.2013.05.001
P407
P577
2013-06-10T00:00:00Z