about
Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosisFas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosisIntestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like propertiesCancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasisActomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growthGEMMs as preclinical models for testing pancreatic cancer therapiesMouse models of intestinal cancerReserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tractThe role of MIZ-1 in MYC-dependent tumorigenesisExploiting inflammation for therapeutic gain in pancreatic cancerMelanoma cells break down LPA to establish local gradients that drive chemotactic dispersalAspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancerCrypt stem cells as the cells-of-origin of intestinal cancerFascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomesGenetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivoDeficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ miceMsh-2 suppresses in vivo mutation in a gene dose and lesion dependent mannerMBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestineDeficiency of Mbd2 attenuates Wnt signalingInducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-cateninTIGAR is required for efficient intestinal regeneration and tumorigenesisLoss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migrationMyc deletion rescues Apc deficiency in the small intestineBrca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cellsThe EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAsConstitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesisSpatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively.Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression.Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion.Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation.Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis.Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo.MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR.MBD2 deficiency does not accelerate p53 mediated lymphomagenesis.PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine.Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine.PPARdelta status and mismatch repair mediated neoplasia in the mouse intestine.A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine.
P50
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P50
description
hulumtues
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onderzoeker
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researcher
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հետազոտող
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name
Owen J Sansom
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Owen J Sansom
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Owen J Sansom
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Owen J Sansom
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Owen J Sansom
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type
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Owen J Sansom
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Owen J Sansom
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Owen J Sansom
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Owen J Sansom
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Owen J Sansom
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Owen J Sansom
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Owen J Sansom
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Owen J Sansom
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Owen J Sansom
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Owen J Sansom
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P106
P2038
Owen_Sansom
P21
P31
P496
0000-0001-9540-3010