The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver
about
Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cellsPbx3 deficiency results in central hypoventilationB-cell development fails in the absence of the Pbx1 proto-oncogeneZebrafish hoxd4a acts upstream of meis1.1 to direct vasculogenesis, angiogenesis and hematopoiesisOverexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradationInvolvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursorsInternal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21Cdkn1a and Pbx1 in Hematopoietic CellsHypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotypePBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter regionHematopoietic, angiogenic and eye defects in Meis1 mutant animals.TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1.Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells.Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites.The TALE homeodomain protein Pbx2 is not essential for development and long-term survivalReduction of Prep1 levels affects differentiation of normal and malignant B cells and accelerates Myc driven lymphomagenesisThe role of meis1 in primitive and definitive hematopoiesis during zebrafish developmentCombination therapy with imatinib mesylate (STI571): synopsis of in vitro studies.The deficiency of tumor suppressor prep1 accelerates the onset of meis1- hoxa9 leukemogenesisPrep1 (pKnox1) regulates mouse embryonic HSC cycling and self-renewal affecting the Stat1-Sca1 IFN-dependent pathway.Reconstruction of the gene regulatory network involved in the sonic hedgehog pathway with a potential role in early development of the mouse brainPbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries.Regulation of hematopoietic stem cell growth.Clinical strategies for expansion of haematopoietic stem cells.Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons.Cis-regulatory mechanisms governing stem and progenitor cell transitionsPbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic NeuronsFar Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels.Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease.Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancerPbx1 is required for adult subventricular zone neurogenesis.Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract.Arsenic trioxide mechanisms of action--looking beyond acute promyelocytic leukemia.Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivo.Common features of megakaryocytes and hematopoietic stem cells: what's the connection?MicroRNA-147 suppresses human hepatocellular carcinoma proliferation migration and chemosensitivity by inhibiting HOXC6.Deciphering the transcriptional network of the dendritic cell lineagePbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth.Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice.The role of HOX genes in normal hematopoiesis and acute leukemia.
P2860
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P2860
The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver
description
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
im August 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/08/01)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/08/01)
@nl
наукова стаття, опублікована в серпні 2001
@uk
مقالة علمية (نشرت في أغسطس 2001)
@ar
name
The Hox cofactor and proto-onc ...... matopoiesis in the fetal liver
@ast
The Hox cofactor and proto-onc ...... matopoiesis in the fetal liver
@en
The Hox cofactor and proto-onc ...... matopoiesis in the fetal liver
@nl
type
label
The Hox cofactor and proto-onc ...... matopoiesis in the fetal liver
@ast
The Hox cofactor and proto-onc ...... matopoiesis in the fetal liver
@en
The Hox cofactor and proto-onc ...... matopoiesis in the fetal liver
@nl
prefLabel
The Hox cofactor and proto-onc ...... matopoiesis in the fetal liver
@ast
The Hox cofactor and proto-onc ...... matopoiesis in the fetal liver
@en
The Hox cofactor and proto-onc ...... matopoiesis in the fetal liver
@nl
P2093
P3181
P356
P1433
P1476
The Hox cofactor and proto-onc ...... matopoiesis in the fetal liver
@en
P2093
I. L. Weissman
J. F. DiMartino
L. Selleri
M. L. Cleary
M. T. Firpo
S. O'Gorman
P304
P3181
P356
10.1182/BLOOD.V98.3.618
P407
P577
2001-08-01T00:00:00Z