Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene
about
Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domainAbsence makes the search grow longerCaenorhabditis elegans as a model organism to study APP functionCortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family membersDelayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit CalphaFE65 as a link between VLDLR and APP to regulate their trafficking and processingMisguided axonal projections, neural cell adhesion molecule 180 mRNA upregulation, and altered behavior in mice deficient for the close homolog of L1Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor proteinSortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesisTruncating mutations in APP cause a distinct neurological phenotype.APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD).Intrasession and intersession habituation in mice: from inbred strain variability to linkage analysis.Systematic analysis of emotionality in consomic mouse strains established from C57BL/6J and wild-derived MSM/Ms.Neurobiology of memory and anxiety: from genes to behavior.A 2cM genome-wide scan of European Holstein cattle affected by classical BSE.Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression.Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.The beta-amyloid precursor protein and its derivatives: from biology to learning and memory processes.APLP2, a member of the Alzheimer precursor protein family, is required for correct genomic segregation in dividing mouse cellsDetermination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase.The functions of the amyloid precursor protein gene.Secretases as therapeutic targets for the treatment of Alzheimer's disease.A method for the generation of conditional gene repair mutations in micePlasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease.A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function.The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signalingNeuroplasticity in Alzheimer's disease.Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin.Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus.Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosis.η-Secretase processing of APP inhibits neuronal activity in the hippocampus.Deficits in axonal transport in hippocampal-based circuitry and the visual pathway in APP knock-out animals witnessed by manganese enhanced MRI.Modulation of human neural stem cell differentiation in Alzheimer (APP23) transgenic mice by phenserine.All in the Family: How the APPs Regulate NeurogenesisTranscription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer diseaseThe keystone of Alzheimer pathogenesis might be sought in Aβ physiologyEnhanced β-secretase processing alters APP axonal transport and leads to axonal defects.Development of beta-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies.Initial locomotor sensitivity to cocaine varies widely among inbred mouse strains.
P2860
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P2860
Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene
description
1994 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1994
@ast
im Dezember 1994 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1994/12/02)
@sk
vědecký článek publikovaný v roce 1994
@cs
wetenschappelijk artikel (gepubliceerd op 1994/12/02)
@nl
наукова стаття, опублікована в грудні 1994
@uk
مقالة علمية (نشرت في 2-12-1994)
@ar
name
Behavioral and anatomical defi ...... amyloid precursor protein gene
@ast
Behavioral and anatomical defi ...... amyloid precursor protein gene
@en
Behavioral and anatomical defi ...... amyloid precursor protein gene
@nl
type
label
Behavioral and anatomical defi ...... amyloid precursor protein gene
@ast
Behavioral and anatomical defi ...... amyloid precursor protein gene
@en
Behavioral and anatomical defi ...... amyloid precursor protein gene
@nl
prefLabel
Behavioral and anatomical defi ...... amyloid precursor protein gene
@ast
Behavioral and anatomical defi ...... amyloid precursor protein gene
@en
Behavioral and anatomical defi ...... amyloid precursor protein gene
@nl
P2093
P3181
P1433
P1476
Behavioral and anatomical defi ...... amyloid precursor protein gene
@en
P2093
C. Weissmann
D. P. Wolfer
H. P. Lipp
N. Cristina
S. Brandner
T. Rülicke
P304
P3181
P356
10.1016/0092-8674(94)90066-3
P407
P577
1994-12-02T00:00:00Z