Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis
about
Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretaseClathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brainsGenes associated with Alzheimer's disease: an overview and current statusGenetic and Transcriptomic Profiles of Inflammation in Neurodegenerative Diseases: Alzheimer, Parkinson, Creutzfeldt-Jakob and TauopathiesThe roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer diseaseNECAP 1 regulates AP-2 interactions to control vesicle size, number, and cargo during clathrin-mediated endocytosisGenetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkersEffects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model.Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearanceAlzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci.Neuroimaging and genetic risk for Alzheimer's disease and addiction-related degenerative brain disorders.Senescence-accelerated OXYS rats: a model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease.Possible modification of Alzheimer's disease by statins in midlife: interactions with genetic and non-genetic risk factorsHippocampal gene expression meta-analysis identifies aging and age-associated spatial learning impairment (ASLI) genes and pathways.Alzheimer's disease risk genes and the age-at-onset phenotype.Single-nucleotide polymorphisms are associated with cognitive decline at Alzheimer's disease conversion within mild cognitive impairment patients.Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesisAn intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALM isoformThe Biochemical Properties and Functions of CALM and AP180 in Clathrin Mediated Endocytosis.Alzheimer's disease risk genes and mechanisms of disease pathogenesisEpistatic genetic effects among Alzheimer's candidate genes.Genetics of PICALM expression and Alzheimer's disease.Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis.Meta-analysis of the Association between Alzheimer Disease and Variants in GAB2, PICALM, and SORL1.Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis.Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer's diseaseATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing.Meta-analysis of association between the genetic polymorphisms on chromosome 11q and Alzheimer's disease susceptibility.Single-Cell Detection of Secreted Aβ and sAPPα from Human IPSC-Derived Neurons and Astrocytes.Beta-amyloid toxicity modifier genes and the risk of Alzheimer's disease.Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta.Phosphatidylinositol 4-kinases and PI4P metabolism in the nervous system: roles in psychiatric and neurological diseases.Alzheimer's disease genetics: from the bench to the clinic.The Role of PICALM in Alzheimer's Disease.Novel susceptibility loci for Alzheimer's disease.Clearance of cerebral Aβ in Alzheimer's disease: reassessing the role of microglia and monocytes.State of Play in Alzheimer's Disease Genetics.Untangling Genetic Risk for Alzheimer's Disease.PICALM gene rs3851179 polymorphism contributes to Alzheimer's disease in an Asian population.Genome-wide significant, replicated and functional risk variants for Alzheimer's disease.
P2860
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P2860
Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis
description
2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2012
@ast
im Juni 2012 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2012/06/15)
@sk
vědecký článek publikovaný v roce 2012
@cs
wetenschappelijk artikel (gepubliceerd op 2012/06/15)
@nl
наукова стаття, опублікована в червні 2012
@uk
name
Role of phosphatidylinositol c ...... nd amyloid plaque pathogenesis
@ast
Role of phosphatidylinositol c ...... nd amyloid plaque pathogenesis
@en
Role of phosphatidylinositol c ...... nd amyloid plaque pathogenesis
@nl
type
label
Role of phosphatidylinositol c ...... nd amyloid plaque pathogenesis
@ast
Role of phosphatidylinositol c ...... nd amyloid plaque pathogenesis
@en
Role of phosphatidylinositol c ...... nd amyloid plaque pathogenesis
@nl
prefLabel
Role of phosphatidylinositol c ...... nd amyloid plaque pathogenesis
@ast
Role of phosphatidylinositol c ...... nd amyloid plaque pathogenesis
@en
Role of phosphatidylinositol c ...... nd amyloid plaque pathogenesis
@nl
P2093
P2860
P921
P3181
P356
P1476
Role of phosphatidylinositol c ...... nd amyloid plaque pathogenesis
@en
P2093
Ernie Gonzales
John R Cirrito
Qingli Xiao
Ronaldo Perez
Sharon Han
So-Chon Gil
P2860
P304
21279-21289
P3181
P356
10.1074/JBC.M111.338376
P407
P50
P577
2012-04-26T00:00:00Z