Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice
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Identification of novel rare mutations of DACT1 in human neural tube defectsProtein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote dishevelled degradationDisruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/β-catenin signalingAll Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinasesHeterozygous Pathogenic Variant in DACT1 Causes an Autosomal-Dominant Syndrome with Features Overlapping Townes-Brocks SyndromeDapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation.Retinoic acid negatively regulates dact3b expression in the hindbrain of zebrafish embryos.Vertebrate intestinal endoderm development.Gene network analysis of candidate loci for human anorectal malformations.The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy.Expression analysis of Dact1 in mice using a LacZ reporter.Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesisPICK1 promotes caveolin-dependent degradation of TGF-β type I receptor.Two types of nanoparticle-based bio-barcode amplification assays to detect HIV-1 p24 antigen.Dapper homolog 1 is a novel tumor suppressor in gastric cancer through inhibiting the nuclear factor-κB signaling pathway.HECT domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting dishevelled for proteasomal degradation.The Genetic Basis of Baculum Size and Shape Variation in Mice.SEC14 and spectrin domains 1 (Sestd1) and Dapper antagonist of catenin 1 (Dact1) scaffold proteins cooperatively regulate the Van Gogh-like 2 (Vangl2) four-pass transmembrane protein and planar cell polarity (PCP) pathway during embryonic developmenDelamination of neural crest cells requires transient and reversible Wnt inhibition mediated by Dact1/2Association analysis of DACT1 genetic variants and gastric cancer risk in a Chinese Han population: a case-control study.SEC14 and Spectrin Domains 1 (Sestd1), Dishevelled 2 (Dvl2) and Dapper Antagonist of Catenin-1 (Dact1) co-regulate the Wnt/Planar Cell Polarity (PCP) pathway during mammalian developmentDapper homolog 1 alpha suppresses metastasis ability of gastric cancer through inhibiting planar cell polarity pathway.A consideration of the evidence that genetic defects in planar cell polarity contribute to the etiology of human neural tube defects.Planar cell polarity signaling in collective cell movements during morphogenesis and disease.Genetic evidence in planar cell polarity signaling pathway in human neural tube defects.Dact1, a Wnt-Pathway Inhibitor, Mediates Human Mesangial Cell TGF-β1-Induced Apoptosis.Myc-interacting zinc-finger protein 1 positively regulates Wnt signalling by protecting Dishevelled from Dapper1-mediated degradation.Leucine repeat adaptor protein 1 interacts with Dishevelled to regulate gastrulation cell movements in zebrafish.Sestd1 Encodes a Developmentally Dynamic Synapse Protein That Complexes With BCR Rac1-GAP to Regulate Forebrain Dendrite, Spine and Synapse Formation.Dapper-1 is essential for Wnt5a induced cardiomyocyte hypertrophy by regulating the Wnt/PCP pathway.
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P2860
Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice
description
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
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artículu científicu espublizáu en 2010
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im April 2010 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2010/04/02)
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vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/04/02)
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наукова стаття, опублікована у квітні 2010
@uk
name
Loss of Dact1 disrupts planar ...... posterior malformation in mice
@ast
Loss of Dact1 disrupts planar ...... posterior malformation in mice
@en
Loss of Dact1 disrupts planar ...... posterior malformation in mice
@nl
type
label
Loss of Dact1 disrupts planar ...... posterior malformation in mice
@ast
Loss of Dact1 disrupts planar ...... posterior malformation in mice
@en
Loss of Dact1 disrupts planar ...... posterior malformation in mice
@nl
prefLabel
Loss of Dact1 disrupts planar ...... posterior malformation in mice
@ast
Loss of Dact1 disrupts planar ...... posterior malformation in mice
@en
Loss of Dact1 disrupts planar ...... posterior malformation in mice
@nl
P2093
P2860
P3181
P356
P1476
Loss of Dact1 disrupts planar ...... posterior malformation in mice
@en
P2093
Jingyue Xu
Y. Jeffrey Chiang
Ye-Guang Chen
Yuanheng Ning
P2860
P304
11023–11030
P3181
P356
10.1074/JBC.M109.085381
P407
P577
2010-04-02T00:00:00Z