Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog
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The Roles of Hedgehog Signaling in Upper Lip FormationHoloprosencephaly: signaling interactions between the brain and the face, the environment and the genes, and the phenotypic variability in animal models and humansA sonic hedgehog missense mutation associated with holoprosencephaly causes defective binding to GAS1The buccohypophyseal canal is an ancestral vertebrate trait maintained by modulation in sonic hedgehog signalingMechanisms that underlie co-variation of the brain and faceGrowth Arrest Specific-1 (GAS1) Is a C/EBP Target Gene That Functions in Ovulation and Corpus Luteum Formation in MiceCan you hear me now? Understanding vertebrate middle ear development.The molecular genetics of holoprosencephaly.Boc modifies the spectrum of holoprosencephaly in the absence of Gas1 functionQuantitative analyses link modulation of sonic hedgehog signaling to continuous variation in facial growth and shapeTNFRSF11B computational development network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients.CDO, an Hh-coreceptor, mediates lung cancer cell proliferation and tumorigenicity through Hedgehog signalingExpression analysis of candidate genes regulating successional tooth formation in the human embryoClinical findings in patients with GLI2 mutations--phenotypic variability.Clinical implications of hedgehog signaling pathway inhibitorsSolution structure and biophysical characterization of the multifaceted signalling effector protein growth arrest specific-1.The Hedgehog pathway: role in cell differentiation, polarity and proliferationPtch1 overexpression drives skin carcinogenesis and developmental defects in K14Ptch(FVB) miceA review of hedgehog signaling in cranial bone developmentThe relationship between sonic Hedgehog signaling, cilia, and neural tube defectsImplications of hedgehog signaling antagonists for cancer therapy.Missense substitutions in the GAS1 protein present in holoprosencephaly patients reduce the affinity for its ligand, SHH.Growth arrest specific 1 (GAS1) is abundantly expressed in the adult mouse central nervous systemSonic hedgehog signalling inhibits palatogenesis and arrests tooth development in a mouse model of the nevoid basal cell carcinoma syndrome.Targeting hedgehog signaling in cancer: research and clinical developments.Pathogenesis of holoprosencephalyActivation of the hedgehog-signaling pathway in human cancer and the clinical implications.Hedgehog signaling and gastrointestinal cancerHedgehog signaling in skin cancersAetiology of supernumerary teeth: a literature review.The epidemiology of supernumerary teeth and the associated molecular mechanism.GAS1 is present in the cerebrospinal fluid and is expressed in the choroid plexus of the adult rat.Growth arrest-specific gene 1 is downregulated and inhibits tumor growth in gastric cancer.GAS1 induces cell death through an intrinsic apoptotic pathway.A genome-wide shRNA screen identifies GAS1 as a novel melanoma metastasis suppressor gene.Induction of autophagy and apoptosis by miR-148a through the sonic hedgehog signaling pathway in hepatic stellate cells.Distinct structural requirements for CDON and BOC in the promotion of Hedgehog signaling.Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferationCOUP-TFII is required for morphogenesis of the neural crest-derived tympanic ring.Genetic interactions between the hedgehog co-receptors Gas1 and Boc regulate cell proliferation during murine palatogenesis.
P2860
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P2860
Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog
description
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im Juni 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/06/01)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/06/01)
@nl
наукова стаття, опублікована в червні 2007
@uk
مقالة علمية (نشرت في يونيو 2007)
@ar
name
Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog
@ast
Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog
@en
Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog
@nl
type
label
Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog
@ast
Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog
@en
Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog
@nl
prefLabel
Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog
@ast
Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog
@en
Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog
@nl
P2093
P2860
P356
P1476
Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog
@en
P2093
Chen-Ming Fan
David C. Martinelli
Maisa Seppala
Michael J. Depew
Paul T. Sharpe
P2860
P304
P356
10.1172/JCI32032
P407
P577
2007-06-01T00:00:00Z