Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia
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RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturationPancreatic ductal cells in development, regeneration, and neoplasiaSilencing Mist1 Gene Expression Is Essential for Recovery from Acute PancreatitisTherapeutic potential of targeting acinar cell reprogramming in pancreatic cancerAberrant localization of intracellular organelles, Ca2+ signaling, and exocytosis in Mist1 null miceTransdifferentiation of pancreatic cells by loss of contact-mediated signalingRAB26 coordinates lysosome traffic and mitochondrial localization.Design and implementation of bimolecular fluorescence complementation (BiFC) assays for the visualization of protein interactions in living cells.Bimolecular fluorescence complementation (BiFC) analysis as a probe of protein interactions in living cells.LEC-BiFC: a new method for rapid assay of protein interaction.Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia.Mist1 regulates pancreatic acinar cell proliferation through p21 CIP1/WAF1KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma.PD2/Paf1 depletion in pancreatic acinar cells promotes acinar-to-ductal metaplasia.Serum clusterin as a tumor marker and prognostic factor for patients with esophageal cancerHnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitorsExpression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreasThe basic helix-loop-helix transcription factor E47 reprograms human pancreatic cancer cells to a quiescent acinar state with reduced tumorigenic potential.Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia.Transcriptional selectors, masters, and combinatorial codes: regulatory principles of neural subtype specificationThe Drosophila basic helix-loop-helix protein DIMMED directly activates PHM, a gene encoding a neuropeptide-amidating enzymeVisualization of molecular interactions by fluorescence complementation.The ubiquitin ligase Mindbomb 1 coordinates gastrointestinal secretory cell maturationMIST1 Links Secretion and Stress as Both Target and Regulator of the UPR.Acinar cell plasticity and development of pancreatic ductal adenocarcinoma.Bimolecular fluorescence complementation: visualization of molecular interactions in living cells.Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia.The big and intricate dreams of little organelles: Embracing complexity in the study of membrane traffic.The bHLH domain of Mistl is sufficient to activate gene transcription.Restoration of functional gap junctions through internal ribosome entry site-dependent synthesis of endogenous connexins in density-inhibited cancer cellsOn the role of lateral stabilization during early patterning in the pancreasSilencing of the Fibroblast growth factor 21 gene is an underlying cause of acinar cell injury in mice lacking MIST1.Murine embryonic stem cell-derived pancreatic acinar cells recapitulate features of early pancreatic differentiation.Metaplasia: tissue injury adaptation and a precursor to the dysplasia-cancer sequence.Mice lacking the transcription factor Mist1 exhibit an altered stress response and increased sensitivity to caerulein-induced pancreatitis.Activation of protein kinase Cδ leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1.
P2860
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P2860
Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia
description
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im April 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/04/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/04/01)
@nl
наукова стаття, опублікована у квітні 2004
@uk
مقالة علمية (نشرت في أبريل 2004)
@ar
name
Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia
@ast
Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia
@en
Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia
@nl
type
label
Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia
@ast
Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia
@en
Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia
@nl
prefLabel
Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia
@ast
Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia
@en
Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia
@nl
P2093
P2860
P1476
Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia
@en
P2093
Barbara Damsz
J. Michael Rukstalis
Peichuan Sun
Stephen F. Konieczny
P2860
P304
P356
10.1128/MCB.24.7.2673-2681.2004
P407
P577
2004-04-01T00:00:00Z