The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning
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MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signalingMammary gland developmentShh and Gli3 regulate formation of the telencephalic-diencephalic junction and suppress an isthmus-like signaling source in the forebrainTHM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in ciliaMouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathwayPhosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse developmentForward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signalingGATA6 is a crucial regulator of Shh in the limb budGata6-Dependent GLI3 Repressor Function is Essential in Anterior Limb Progenitor Cells for Proper Limb DevelopmentMutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathiesLimb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3Generation of mice with functional inactivation of talpid3, a gene first identified in chickenExome sequencing identifies a recurrent de novo ZSWIM6 mutation associated with acromelic frontonasal dysostosis.The primary cilium as a complex signaling centerInactivation of Patched1 in the mouse limb has novel inhibitory effects on the chondrogenic program.Urogenital development in Pallister-Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor.Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary ciliumPoint mutations in GLI3 lead to misregulation of its subcellular localization.Sonic hedgehog expression and its role in form-deprivation myopia in mice.Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors.Hedgehog signaling in the normal and neoplastic mammary gland.Sonic hedgehog signaling in the postnatal brain.Hedgehog activity controls opening of the primary mouth.Increased proteolytic processing of full-length Gli2 transcription factor reduces the hedgehog pathway activity in vivo.HMGB factors are required for posterior digit development through integrating signaling pathway activitiesThe Hedgehog transcription factor Gli3 modulates angiogenesis.A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome.Suppressor of Fused Is Required for Determining Digit Number and Identity via Gli3/Fgfs/GremlinSmall ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo.Joint interpretation of AER/FGF and ZPA/SHH over time and space underlies hairy2 expression in the chick limb.T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number.The primary cilium at the crossroads of mammalian hedgehog signalingDominant activation of the hedgehog signaling pathway in the ovary alters theca development and prevents ovulation.Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells.A Gli silencer is required for robust repression of gremlin in the vertebrate limb bud.Transcriptional regulation of graded Hedgehog signalingAdvances in the molecular genetics of non-syndromic polydactyly.GLI3 repressor determines Hedgehog pathway activation and is required for response to SMO antagonist glasdegib in AML.Tibial hemimelia associated with GLI3 truncation.Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation.
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P2860
The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning
description
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im Mai 2007 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2007/05/15)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/05/15)
@nl
наукова стаття, опублікована в травні 2007
@uk
مقالة علمية (نشرت في 15-5-2007)
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name
The Shh-independent activator ...... rtebrate limb digit patterning
@ast
The Shh-independent activator ...... rtebrate limb digit patterning
@en
The Shh-independent activator ...... rtebrate limb digit patterning
@nl
type
label
The Shh-independent activator ...... rtebrate limb digit patterning
@ast
The Shh-independent activator ...... rtebrate limb digit patterning
@en
The Shh-independent activator ...... rtebrate limb digit patterning
@nl
prefLabel
The Shh-independent activator ...... rtebrate limb digit patterning
@ast
The Shh-independent activator ...... rtebrate limb digit patterning
@en
The Shh-independent activator ...... rtebrate limb digit patterning
@nl
P2093
P2860
P3181
P1476
The Shh-independent activator ...... rtebrate limb digit patterning
@en
P2093
Baolin Wang
Chengbing Wang
Ulrich Rüther
P2860
P304
P3181
P356
10.1016/J.YDBIO.2007.02.029
P407
P577
2007-05-15T00:00:00Z