Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality
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Using engineered 2-O-sulfotransferase to determine the activity of heparan sulfate C5-epimerase and its mutantsThe human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathwayD-glucuronyl C5-epimerase acts in dorso-ventral axis formation in zebrafishThe Extracellular Matrix in Bronchopulmonary Dysplasia: Target and SourceMolecular basis of cleft palates in micePathophysiology of heparan sulphate: many diseases, few drugsHuman genetic disorders and knockout mice deficient in glycosaminoglycanHeparan sulfate proteoglycans in the control of B cell development and the pathogenesis of multiple myelomaEnzymatic modifications of exopolysaccharides enhance bacterial persistenceHeparan sulfate biosynthesis enzymes in embryonic stem cell biologyCatalytic Mechanism and Mode of Action of the Periplasmic Alginate Epimerase AlgGNewly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinasesSulfatase 1 is an inhibitor of ductal morphogenesis with sexually dimorphic expression in the urogenital sinusMice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethalityFibroblast growth factors share binding sites in heparan sulphate.3-O-sulfated oligosaccharide structures are recognized by anti-heparan sulfate antibody HS4C3.Characterization of anti-heparan sulfate phage display antibodies AO4B08 and HS4E4.The 3'-phosphoadenosine 5'-phosphosulfate transporters, PAPST1 and 2, contribute to the maintenance and differentiation of mouse embryonic stem cellsLoss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in miceHeparan sulfate domain organization and sulfation modulate FGF-induced cell signalingSimilarity of recombinant human perlecan domain 1 by alternative expression systems bioactive heterogenous recombinant human perlecan D1.Hs2st mediated kidney mesenchyme induction regulates early ureteric bud branchingQuantitative trait loci for energy balance traits in an advanced intercross line derived from mice divergently selected for heat loss.In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosisStructure and epitope distribution of heparan sulfate is disrupted in experimental lung hypoplasia: a glycobiological epigenetic cause for malformation?Combinatorial roles of heparan sulfate proteoglycans and heparan sulfates in Caenorhabditis elegans neural development.Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouseAmino acid substitutions in the E2 glycoprotein of Sindbis-like virus XJ-160 confer the ability to undergo heparan sulfate-dependent infection of mouse embryonic fibroblasts.Irreversible glucuronyl C5-epimerization in the biosynthesis of heparan sulfate.Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and arteminDermatan sulfate epimerase 1 deficient mice as a model for human abdominal wall defectsImpairment of glycosaminoglycan synthesis in mucopolysaccharidosis type IIIA cells by using siRNA: a potential therapeutic approach for Sanfilippo disease.In vivo manipulation of heparan sulfate structure and its effect on Drosophila developmentLacrimal gland development and Fgf10-Fgfr2b signaling are controlled by 2-O- and 6-O-sulfated heparan sulfate.Genetic analysis of the heparan modification network in Caenorhabditis elegansStage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling.Heparan sulfate proteoglycans.Heparan sulfate expression in the neural crest is essential for mouse cardiogenesis.Structural and functional study of D-glucuronyl C5-epimeraseD-glucuronyl C5-epimerase suppresses small-cell lung cancer cell proliferation in vitro and tumour growth in vivo.
P2860
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P2860
Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality
description
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2003
@ast
im August 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/08/01)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/08/01)
@nl
наукова стаття, опублікована в серпні 2003
@uk
name
Targeted disruption of a murin ...... acid and in neonatal lethality
@ast
Targeted disruption of a murin ...... acid and in neonatal lethality
@en
Targeted disruption of a murin ...... acid and in neonatal lethality
@nl
type
label
Targeted disruption of a murin ...... acid and in neonatal lethality
@ast
Targeted disruption of a murin ...... acid and in neonatal lethality
@en
Targeted disruption of a murin ...... acid and in neonatal lethality
@nl
prefLabel
Targeted disruption of a murin ...... acid and in neonatal lethality
@ast
Targeted disruption of a murin ...... acid and in neonatal lethality
@en
Targeted disruption of a murin ...... acid and in neonatal lethality
@nl
P2093
P3181
P356
P1476
Targeted disruption of a murin ...... acid and in neonatal lethality
@en
P2093
Asa Hagner-McWhirter
Erik Forsberg
Jin-Ping Li
Magnus Abrink
Robert Kisilevsky
Xiao Zhang
P304
28363–28366
P3181
P356
10.1074/JBC.C300219200
P407
P50
P577
2003-08-01T00:00:00Z