Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases - Wikidata - awgldk - TriplyDB

Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases

Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases

http://www.wikidata.org/entity/Q28475274

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Heparanase activity in alveolar and embryonal rhabdomyosarcoma: implications for tumor invasion Pathophysiology of heparan sulphate: many diseases, few drugs Towards understanding the roles of heparan sulfate proteoglycans in Alzheimer's disease Heparan sulfate biosynthesis enzymes in embryonic stem cell biology Mast cell proteoglycans Involvement of heparanase in atherosclerosis and other vessel wall pathologies Accelerated resolution of AA amyloid in heparanase knockout mice is associated with matrix metalloproteases Heparanase affects food intake and regulates energy balance in mice Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1.Heparanase and hepatocellular carcinoma: promoter or inhibitor?Heparanase cooperates with Ras to drive breast and skin tumorigenesis Combination therapy with low molecular weight heparin and Adriamycin results in decreased breast cancer cell metastasis in C3H mice.Tumorigenic and adhesive properties of heparanase.Dissociation between mature phenotype and impaired transmigration in dendritic cells from heparanase-deficient mice.Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis.Prognostic value of heparanase expression and cellular localization in oral cancer.Functional screen of paracrine signals in breast carcinoma fibroblasts.MicroRNA-1258 suppresses breast cancer brain metastasis by targeting heparanase.Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling.Heparan sulfate proteoglycans.Macrophage polarization in pancreatic carcinoma: role of heparanase enzyme.Heparanase affects secretory granule homeostasis of murine mast cells through degrading heparin Protease Activity and the Role of the Endothelial Glycocalyx in Inflammation.Involvement of Heparanase in Empyema: Implication for Novel Therapeutic Approaches The role of heparanase in pulmonary cell recruitment in response to an allergic but not non-allergic stimulus.Expression of heparanase in vascular cells and astrocytes of the mouse brain after focal cerebral ischemia.Heparanase Enhances Tumor Growth and Chemoresistance by Promoting Autophagy Significance of heparanase in cancer and inflammation.Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity Two classes of matrix metalloproteinases reciprocally regulate synaptogenesis.Heparanase localization during palatogenesis in mice.The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes Impact of heparanase and the tumor microenvironment on cancer metastasis and angiogenesis: basic aspects and clinical applications The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis.Heparanase: busy at the cell surface.Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3 Heparanase is required for activation and function of macrophages.Blood vessels pattern heparan sulfate gradients between their apical and basolateral aspects.Cell-autonomous heparanase modulates self-renewal and migration in bone marrow-derived mesenchymal stem cells The endothelial glycocalyx as a barrier to leukocyte adhesion and its mediation by extracellular proteases.

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Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases

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Newly generated heparanase kno ...... and matrix metalloproteinases

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Newly generated heparanase kno ...... and matrix metalloproteinases

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Eyal Zcharia

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Juan Jia

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P2860

Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis

Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member

Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation

Heparanase induces endothelial cell migration via protein kinase B/Akt activation

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis

Identification of active-site residues of the pro-metastatic endoglycosidase heparanase

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

Substrate specificity of heparanases from human hepatoma and platelets

Heparanase in glomerular diseases

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Israel Vlodavsky

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