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Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesisTumor microenvironment and neurofibromatosis type I: connecting the GAPsMouse models of neurofibromatosis 1 and 2.RASopathies: unraveling mechanisms with animal modelsEliminating barriers to personalized medicine: learning from neurofibromatosis type 1A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressorJCV T-antigen interacts with the neurofibromatosis type 2 gene product in a transgenic mouse model of malignant peripheral nerve sheath tumorsNeurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytesNf1 has an essential role in endothelial cellsOvca1 regulates cell proliferation, embryonic development, and tumorigenesisQuantitative assessment of whole-body tumor burden in adult patients with neurofibromatosisOptimizing biologically targeted clinical trials for neurofibromatosis.Molecular mechanisms promoting the pathogenesis of Schwann cell neoplasmsZebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development.Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI.Epidermal growth factor receptor expression in neurofibromatosis type 1-related tumors and NF1 animal modelsMouse models of human familial cancer syndromes.Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis.Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity.tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors.Malignant Peripheral Nerve Sheath Tumors State of the Science: Leveraging Clinical and Biological Insights into Effective Therapies.Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signalingPlexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells.Cis lethal genetic interactions attenuate and alter p53 tumorigenesis.Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis.Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis.DNA damage, somatic aneuploidy, and malignant sarcoma susceptibility in muscular dystrophies.Treatment of orthotopic malignant peripheral nerve sheath tumors with oncolytic herpes simplex virus.Zebrafish models of p53 functions.MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1.Neoplasms associated with germline and somatic NF1 gene mutationsMolecular and cellular mechanisms underlying the cognitive deficits associated with neurofibromatosis 1.Genome-wide Twist1 occupancy in endocardial cushion cells, embryonic limb buds, and peripheral nerve sheath tumor cells.Neurofibromatosis type 1: II. Answers from animal models.First-line chemotherapy for malignant peripheral nerve sheath tumor (MPNST) versus other histological soft tissue sarcoma subtypes and as a prognostic factor for MPNST: an EORTC soft tissue and bone sarcoma group studyMouse models of inherited cancer syndromesAn imprinted locus epistatically influences Nstr1 and Nstr2 to control resistance to nerve sheath tumors in a neurofibromatosis type 1 mouse model.Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection.Harnessing preclinical mouse models to inform human clinical cancer trials.Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma.
P2860
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P2860
description
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Science
@fr
artículu científicu espublizáu en 1999
@ast
im Dezember 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/12/10)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/12/10)
@nl
наукова стаття, опублікована в грудні 1999
@uk
name
Mouse tumor model for neurofibromatosis type 1
@ast
Mouse tumor model for neurofibromatosis type 1
@en
Mouse tumor model for neurofibromatosis type 1
@nl
type
label
Mouse tumor model for neurofibromatosis type 1
@ast
Mouse tumor model for neurofibromatosis type 1
@en
Mouse tumor model for neurofibromatosis type 1
@nl
prefLabel
Mouse tumor model for neurofibromatosis type 1
@ast
Mouse tumor model for neurofibromatosis type 1
@en
Mouse tumor model for neurofibromatosis type 1
@nl
P2093
P2860
P3181
P1433
P1476
Mouse tumor model for neurofibromatosis type 1
@en
P2093
E. J. Rushing
K. S. Vogel
L. F. Parada
L. J. Klesse
S. Velasco-Miguel
P2860
P304
P3181
P356
10.1126/SCIENCE.286.5447.2176
P407
P577
1999-12-10T00:00:00Z