about
P688
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaBNeurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cellsTargeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissuesNeurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivoLoss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cellsNeurofibromin binds to caveolin-1 and regulates ras, FAK, and AktNf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemiaJCV T-antigen interacts with the neurofibromatosis type 2 gene product in a transgenic mouse model of malignant peripheral nerve sheath tumorsAblation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brainNeurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytesNf1 and Gmcsf interact in myeloid leukemogenesisInduction of melanogenic abnormalities in NF1+/- mutant mice by DMBANf1 has an essential role in endothelial cellsNeurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cellsSomatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorderGlioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytesIn vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cellsThe neurofibromatosis type 1 (Nf1) tumor suppressor is a modifier of carcinogen-induced pigmentation and papilloma formation in C57BL/6 miceNeurofibromin negatively regulates neurotrophin signaling through p21ras in embryonic sensory neuronsNf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effectsGlycogen stored in skeletal but not in cardiac muscle in acid alpha-glucosidase mutant (Pompe) mice is highly resistant to transgene-encoded human enzymeRole of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cellsLong-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signalingNf1 haploinsufficiency augments angiogenesisAnalysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survivalNeurofibromin, the neurofibromatosis type 1 Ras-GAP, is required for appropriate P0 expression and myelinationThe neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 miceGenetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivoThe HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferaseNeurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cellsThe Nf1 tumor suppressor regulates mouse skin wound healing, fibroblast proliferation, and collagen deposited by fibroblastsLoss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neuronsNeurofibromin deficiency in mice causes exencephaly and is a modifier for Splotch neural tube defectsA mouse model for the learning and memory deficits associated with neurofibromatosis type IHaploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferationMouse models of tumor development in neurofibromatosis type 1Mouse tumor model for neurofibromatosis type 1Aberrant growth and differentiation of oligodendrocyte progenitors in neurofibromatosis type 1 mutants
P921
Q24299235-00EB4598-28BA-4355-9B77-CA87D2677594Q24322602-68EDFD13-AC82-4041-A0B8-45D11A5E1CF1Q28238680-D659BCB6-76A7-439F-988C-248B0A2BEB5BQ28504560-A2679156-B7F7-4FF3-AADD-869D169DCDF1Q28504730-D428BFAA-7718-43C8-83A7-A9683B3B5383Q28505498-74D11F78-2D96-44C5-A03D-B16EEC2AF60FQ28505914-BC50A217-8B21-4442-A531-ADA57F08CA21Q28506719-A997CDB0-8221-4B2D-B74D-90D214A8E149Q28506943-E1F0A304-9B1A-4565-B7D1-519D06C70B0DQ28506980-5FA9D65B-2A62-4C2F-B14D-35BBA166978AQ28507018-C5FCF27F-A54F-4838-B4E9-8E87C0DE17D4Q28507448-9B3580D1-413F-4166-AC5B-4F9098F9F327Q28507662-7AA71A4E-4BD8-494E-85A8-3D065B58002FQ28508149-CE5D226C-CA5F-4354-81DF-EBB9D98D4FCAQ28508406-E3EEB51E-59E1-4303-A4A3-1D87BEA70816Q28510368-AD02C477-B8D9-4506-8ED9-84E1C5E940BBQ28510694-5BBEBA42-D74F-4E4A-8805-13A547732EA6Q28511045-49A4BDB1-826C-4254-82DA-913162C6CB40Q28511423-AB2F394A-D0CE-46B4-B84E-C90BDC658E68Q28511432-244D97A6-AE9C-4EF9-A73D-3DF36F8F08C5Q28511802-FE96EE0D-D130-4B2A-BE31-407090F76F59Q28511967-BC4ABF20-1673-4B12-8869-BE7401EA7299Q28512108-0F07C936-00C6-43DC-A0DB-EE87F0E2C267Q28512109-B8F8227A-62A3-431F-866E-AB1B9035806EQ28512918-FBAF985A-52D4-4082-8FD4-ED402834E89DQ28513147-016958CF-F8A5-40D7-9847-A196A295292AQ28513847-DA90D087-BDDB-456B-A02B-BA293BAF8615Q28585229-9D264692-11E7-4412-BAE9-43161A77EA5CQ28585945-4FFBFC3E-47A9-4A36-9E43-2B5604AD5E37Q28586111-CCD4DFB2-A2CA-4BF7-BC99-240A917705F7Q28588037-EA3A9710-D3FD-46C5-B72E-DFC857A2E858Q28589155-70808AC4-9A77-4756-98DD-E16E4989869AQ28590121-E4C282DA-C0A5-4C5F-BFDE-0E39C4B310FCQ28590132-A40EB401-1391-488C-871D-BD53330C79A9Q28590322-D99747DE-FEAD-48EC-A3F1-D286AAF4C763Q28590440-8208A684-B44E-43AB-81AE-DFB5FF366A38Q28590575-23F72D40-C05B-4FE4-9498-9E99D0119280Q28591083-47D83F53-9D67-4C20-9A01-AA63C3E2B1F3Q28591456-7EE86F63-B850-4CB6-8B4C-C93369646971Q28591548-FAD4F2C6-CDB9-4450-94B8-7EA84F640C51
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
proteinë
@sq
proteïne in Neurofibromin 1
@nl
protèin
@ace
بروتين في فأر المنازل
@ar
name
Neurofibromin 1
@en
type
label
Neurofibromin 1
@en
altLabel
Nf1
@en
neurofibromatosis 1
@en
neurofibromatosis-related protein NF-1
@en
neurofibromin
@en
prefLabel
Neurofibromin 1
@en
P637
P680
P681
P682
P705
P352
P637
P31
P352
P637
XP_006532499
XP_006532500
XP_006532501
XP_006532502
XP_006532503
XP_006532504
XP_006532505
XP_030101504
P680
P681
P682
P702
P703
P705
ENSMUSP00000071289
ENSMUSP00000103886
ENSMUSP00000120982
ENSMUSP00000151975