RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation
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RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cellsSpecificity in Ras and Rap signalingT cell activationConcerning immune synapses: a spatiotemporal timelineThe Skap-hom Dimerization and PH Domains Comprise a 3′-Phosphoinositide-Gated Molecular SwitchRap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detectorQuantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hubThe N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms.The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells.Actin polymerization-dependent activation of Cas-L promotes immunological synapse stabilityNDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization.ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding.HPK1 associates with SKAP-HOM to negatively regulate Rap1-mediated B-lymphocyte adhesion.Role for ADAP in shear flow-induced platelet mechanotransduction.An improved transplantation strategy for mouse mesenchymal stem cells in an acute myocardial infarction model.Binding properties and stability of the Ras-association domain of Rap1-GTP interacting adapter molecule (RIAM).The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation.ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.Analysis of Phosphorylation-dependent Protein Interactions of Adhesion and Degranulation Promoting Adaptor Protein (ADAP) Reveals Novel Interaction Partners Required for Chemokine-directed T cell Migration.Rap1 and its effector RIAM are required for lymphocyte trafficking.Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in miceSLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1.The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1.Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activationDistinct regulation of integrin-dependent T cell conjugate formation and NF-kappa B activation by the adapter protein ADAP.Identifying Yersinia YopH-targeted signal transduction pathways that impair neutrophil responses during in vivo murine infectionSKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion.T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodesSignal transduction during activation and inhibition of natural killer cells.The ins and outs of leukocyte integrin signaling.The cellular context of T cell signaling.The Role of SH2 Domain-containing Leukocyte Phosphoprotein of 76 kDa in the Regulation of Immune Cell Development and FunctionCoordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76The insider's guide to leukocyte integrin signalling and function.Integrin signalling and function in immune cells.The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties.Signal transduction pathways in chronic inflammatory autoimmune disease: small GTPases.The Rap1-RIAM-talin axis of integrin activation and blood cell functionPositive and negative regulation by SLP-76/ADAP and Pyk2 of chemokine-stimulated T-lymphocyte adhesion mediated by integrin α4β1
P2860
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P2860
RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation
description
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im Juni 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/06/01)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/06/01)
@nl
наукова стаття, опублікована в червні 2007
@uk
مقالة علمية (نشرت في يونيو 2007)
@ar
name
RIAM links the ADAP/SKAP-55 si ...... r-mediated integrin activation
@ast
RIAM links the ADAP/SKAP-55 si ...... r-mediated integrin activation
@en
RIAM links the ADAP/SKAP-55 si ...... r-mediated integrin activation
@nl
type
label
RIAM links the ADAP/SKAP-55 si ...... r-mediated integrin activation
@ast
RIAM links the ADAP/SKAP-55 si ...... r-mediated integrin activation
@en
RIAM links the ADAP/SKAP-55 si ...... r-mediated integrin activation
@nl
prefLabel
RIAM links the ADAP/SKAP-55 si ...... r-mediated integrin activation
@ast
RIAM links the ADAP/SKAP-55 si ...... r-mediated integrin activation
@en
RIAM links the ADAP/SKAP-55 si ...... r-mediated integrin activation
@nl
P2093
P2860
P921
P3181
P356
P1476
RIAM links the ADAP/SKAP-55 si ...... r-mediated integrin activation
@en
P2093
Burkhart Schraven
Emily J. H. Chen
Gary Koretzky
Stefanie Kliche
Theresia E. B. Stradal
P2860
P304
P3181
P356
10.1128/MCB.02011-06
P407
P577
2007-06-01T00:00:00Z